Browse > Article

Study of Immunosuppressive Activity and Insulin Secretion by Treated Sanguisorba Officinalis  

Hwang, Seock Yeon (Department of Biomedical Laboratory Science, College of Natural Science, Daejeon University)
Kim, Myung Hyun (Department of Physiology, College of Korean Medicine, Daejeon University)
Kang, Jung Soo (Department of Physiology, College of Korean Medicine, Daejeon University)
Kim, Byoung Soo (Department of Physiology, College of Korean Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.28, no.5, 2014 , pp. 499-505 More about this Journal
Abstract
Immunosuppressors cyclosporine A(CsA) and tacrolimus(FK506), the primary cellular target of which is calcineurin/nuclear factor of activated T cells(NFAT) signalling pathways, decrease beta-cell insulin content and mRNA expression. The posttransplantation diabetes mellitus(PTDM) is a frequent complication in immunosuppressive therapy. The present study was to examine the effect of a crude water extracts of medicinal herbs such as Sanguisorba officinalis(SOE) on the immunosuppressive activity with lymphocyte and insulin secretion in insulinoma cell lines with RIN-5mF. It was found that SOE treatment had effect of immunosuppressor on lymphocytes and also significantly increased insulin secretion in RIN-5mF compared to other agents. we might suggest a mechanism on insulin secretion by HNF4a. Taken together, the present study suggested that SOE might serve as immunosuppressive drug in PTDM.
Keywords
Sanguisorba officinalis; immunosuppressor; insulin secretion; HNF-$4{\alpha}$;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Lehto, M., Bitzen, P.O., Isomaa, B., Wkperno, C., Wessman, Y., Forsblom, C., Tuomi, T., Taskinen, M.R., Groop, L. Mutation in the HNF-4$\alpha$ gene affects insulin secretion and triglyceride metabolism. Diabetes 48: 423-425, 1999.   DOI
2 Borlak, J., Niehof, M. HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus. PLoS One. 4(3):e4662, 2009.   DOI
3 David, D.S., Cheigh, J.S., Braun, D.W., Jr. Fotino, M., Stenzel, K.H., Rubin, A.L. HLA-A28 and steroid-induced diabetes in renal transplant patients. JAMA 243: 532-533, 1980.   DOI
4 Ekstrand, A.V., Eriksson, J.G., Gronhagen-Riska, C., Ahonen, P.J., Groop, L.C. Insulin resistance and insulin deficiency in the pathogenesis of posttransplantation diabetes in man. Transplantation 53: 563-569, 1992.   DOI
5 Midtvedt, K., Hartmann, A., Hjelmesath, J., Lund, K., Bjerkely, B.L. Insulin resistance is a common denominator of post-transplant diabetes mellitus and impaired glucose tolerance in renal transplant recipients. Nephrol Dial Transplant 13: 427-431, 1998.   DOI
6 Stoffel, M., Duncan, S.A. The maturity-onset diabetes of the young (MODY1) transcription factor HNF-4$\alpha$ regulates expression of genes required for glucose transport and metabolism. Proc Natl Acad Sci U.S.A 94: 13209-13214, 1997.   DOI   ScienceOn
7 Hwang, J.S. MODY Syndrome. Journal of Korean Society of Pediatric Endocrinology, 15(1):1-6, 2010.
8 Heman, W.H., Fajans, S.S., Smith, M.J., Polonsky, K.S., Bell, G.I., Halter, J.B. Diminished insulin and glucagons secretory responses to arginine in nondiabetic sugjects with a mutation in the hepatocyte nuclear factor 4A/MODY 1 gene. Diabetes 46: 1749-1754, 1997.   DOI
9 Wang, H., Malchler, P., Antirlozzi, P.A., Hagenfeldt, K.A. HNF-4$\alpha$ regulates the expression of pancreatic beta cell genes implicated in glucose metabolism and nutrient-induced insulin secretion. J. Biol Chem 275: 35953-35959, 2000.   DOI   ScienceOn
10 Rissanen, J., Wang, H., Miettinen, R., Karkkainen, P., Mykkanen, L., Kuusisto, J., Karhapaa, P., Niskanen, L., Uusitapa, M., Laakso, M. Variants in the hepatocyte nuclear factor-1$\alpha$ and 4$\alpha$ genes in Finnish and Chinese subjects with late-onset type2 diabetes. Diabetes care 23: 1533-1538, 2000.   DOI   ScienceOn
11 Cereghini, S. Liver-enriched transcription factors and hepatocyte differentiation. FASEB J 10: 267-282, 1996.
12 Heit, J.J., Apelqvist, A.A., Gu, X., Winslow, M.M., Neilson, J.R., Crabtree, G.R., Kim, S.K. Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature. 443(7109):345-349, 2006.   DOI
13 Heit, J.J. Calcineurin/NFAT signaling in the beta-cell: From diabetes to new therapeutics. Bioessays. Oct; 29(10):1011-1021, 2007.   DOI
14 Boudreaux, J.P., McHugh, L., Canafax, D.M., Ascher, N., Sutherland, D.E., Payne, W., Simmons, R.L., Najarian, J.S., Fryd, D.S. The impact of cyclosporine and combination immunosuppression on the incidence of posttransplant diabetes in renal allograft recipients. Transplantation 44: 376-381, 1987.   DOI   ScienceOn
15 Gunnarsson, R., Arner, P., Lundgren, G., Magnusson, G., Ostman, J., Groth, C.G. Diabetes mellitus a more common than believed complication of renal transplantation. Transplant Proc 11: 1280-1281, 1979.
16 Hur, K.Y., Kim, M.S., Kim, Y.S., Kang, E.S., Nam, J.H., Kim, S.H., et al. Risk factors associated with the onset and progression of posttransplantation diabetes in renal allograft recipients. Diabetes Care, 30: 609-615, 2007.   DOI   ScienceOn
17 Sumrani, N.B., Delaney, V., Ding, Z.K., Davis, R., Daskalakis, P., Friedman, E.A., Butt, K.M., Hong, J.H. Diabetes mellitus after renal transplantation in the cyclosporine era-an analysis of risk factors. Transplantation 51: 343-347, 1991.   DOI   ScienceOn
18 Arner, P., Gunnarsson, R., Blomdahl, S., Groth, C.G. Some characteristics of steroid diabetes: a study in renal transplant recipients receiving high-dose corticosteroid therapy. Diabetes Care 6: 23-25, 1983.   DOI   ScienceOn
19 McIntyre, E.A., Walker, M. Genetics of type 2 diabetes and insulin resistance: knowledge from human studies. Clin Endocrinol (Oxf) 57: 303-311, 2002.   DOI
20 Reisaeter, A.V., Hartmann, A. Risk factors and incidence of posttransplant diabetes mellitus. Transplant Proc 33(suppl 5A):8S-18S, 2001.   DOI   ScienceOn
21 Elena, A.G., Petrichenko, V.M., Solodnikov, S.U., Suhinina, T.V., Kline, M.A., Glenn, C., Chi, N. and Howard, M. Anticancer and antithrombin activity of Russian plants. J. Ethnophamacol. 81: 337-342, 2002.   DOI   ScienceOn
22 Michael C. Lawrence, Harshika S. Bhatt, Jeannette M. Watterson, And Richard A. Easom: Regulation of Insulin Gene Transcription by a Ca2+ Responsive Pathway Involving Calcineurin and Nuclear Factor of Activated T Cells. Molecular Endocrinology 15(10):1758-1767, 2001.   DOI
23 Yoshihiro, M., Masato, F., Akihito, Y., Yukata, S., Shigenori, F. and Hiroshi, S. Triterpene glycosides from the roots Sanguisorba officinalis. Phytochemistry 57, 773-779, 2001.   DOI   ScienceOn
24 Kokoska, L., Polesny, Z., Raba, V., Nepovim, A. and Vanek, T. Screening of some Siberian medicinal plants for antimicrobial activity. J. Ethnophamacol. 82: 51-53, 2002.   DOI   ScienceOn
25 Miles, A.M., Sumrani, N., Horowitz, R., Homel, P., Maursky, V., Markell, M.S., Distant, D.A., Hong, J.H., Sommer, B.G., Friedman, E.A. Diabetes mellitus after renal transplantation. Transplantation 65: 380-384, 1998.   DOI   ScienceOn
26 Yun, Y.S. Immunosuppressant in Kidney transplantation. Kidney Research and Clinical Practice:13(supplement 8), pp 66-85, 1994.
27 Kim, E.S., Kim, Y.I., Song, J.G. Immunosuppressant. In-depth data analysis report. KISTI, pp 25-26, 2003.
28 Dambrin, C., Klupp, J., Morris, R.E. Pharmacodynamics of immunosuppressive drusgs. Current opinion in Immunology 12: 557-562, 2000.   DOI   ScienceOn
29 Herbal Medicine, Seoul, Young rim, p 434, 20070
30 Lim, J.P. Herb biochemistry. Sinil books. 247, 2003.
31 Jin, J.P., Jang, J.S. Dictionary of Medical Herb for edible & medicinal, Bubin Publishers Co., Seoul, 2013.
32 Biemond, P., Swaak, A. J., van Eijk, H. G. and Koster, J. F. Superoxide dependent iron release from ferritin in inflammatory disease. Free Radic. Biol. Med. 4: 185-198, 1988.   DOI   ScienceOn
33 Kang, B.S., Ko, U.C., Kim, S.H., No, S.H., Shin, Y.B., Song, H.J., Shin, M.G., Ann, D.G., Lee, S.I., Lee, Y.J., Lee, T.H. and Ju, Y.S. Collaboration with a national college of oriental medicine herbology professor association. In Herbology. Yonglim Press, Seoul, Korea. pp 392-393, 1994.
34 Kasiske, B.L., Snyder, J.J., Gilbertson, D., Matas, A.J. Diabetes mellitus after kidney transplantation in the United States. Am J Transplant 3: 178-185, 2003.   DOI   ScienceOn