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Anti-Depressive Effects of OnDam-Tang with Addition of Linderae Radix (ODT-L) after Chronic Immobilization Stress in C57BL/6 Mice  

Lee, Eun Hee (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University)
Jung, In Chul (Department of Neuropsychiatry, College of Korean Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.28, no.4, 2014 , pp. 403-410 More about this Journal
Abstract
The purpose of this study was to examine the anti-depressive effects of OnDam-Tang with addition of Linderae Radix (ODT-L) on the animal model of depression induced by chronic immobilization stress. Depression model was made by chronic immobilization stress for 2 hours for 21 days. And we performed forced swimming test, analysis of the neurotransmitter and immunohistochemical staining, measured expression levels of serotonin in the brain. ODT-L has decreased immobilization time in forced swimming test. ODT-L has increased amount of melatonin in the brain. ODT-L has increased expression levels of serotonin in the brain. ODT-L prevented damage in the hippocampal region. ODT-L has reduced the expression level of CRF receptors in in hippocampus region. These results suggest that ODT-L may have anti-depressive effects on depression.
Keywords
OnDam-Tang with addition of Linderae Radix (ODT-L); Immobilization stress; Anti-depressive effect; Depression; Serotonin;
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Times Cited By KSCI : 2  (Citation Analysis)
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