Browse > Article

Effects of Flos Sophorae Ethanol Extract on NF-${\kappa}B$ Dependent MMP-9 Expression in Human Breast Cancer Cell  

Kim, Jeong Mi (Center for Metabolic Function Regulation, Wonkwang University School of Medicine)
Lee, Young Rae (Center for Metabolic Function Regulation, Wonkwang University School of Medicine)
Hwang, Jin Ki (Center for Metabolic Function Regulation, Wonkwang University School of Medicine)
Kim, Mi Seong (Center for Metabolic Function Regulation, Wonkwang University School of Medicine)
Kim, Ha Rim (Center for Metabolic Function Regulation, Wonkwang University School of Medicine)
Park, Yeon Ju (Center for Metabolic Function Regulation, Wonkwang University School of Medicine)
You, Yong Ouk (Department of Oral Biochemistry, and Institute of Biomaterials.Implant, School of Dentistry, Wonkwang University)
Kim, Seong Cheol (Department of Korean Physiology, School of Korean Medicine, Wonkwang University)
Ryu, Do Gon (Department of Korean Physiology, School of Korean Medicine, Wonkwang University)
Kwon, Kang Beom (Department of Korean Physiology, School of Korean Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.28, no.1, 2014 , pp. 22-28 More about this Journal
Abstract
Flos Sophorae, the dried flower bud of Sophora japonica L, possesses anti-inflammatory properties, prevents and treats blood capillary and hypertension diseases and can also be used as a hemostat. However, the effect of Flos Sophorae on breast cancer invasion is unknown. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix, is a major component in cancer cell invasion. In this study, we investigated the inhibitory effect of Flos Sophorae extract (FSE) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Matrix metalloproteinase-9 (MMP-9) expression and cell invasion, as well as the molecular mechanisms involved in Michigan Cancer Foundation-7 (MCF-7) cells. FSE inhibited the TPA-induced transcriptional activation of nuclear factor-kappa B (NF-${\kappa}B$). These results indicate that FSE-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of NF-${\kappa}B$ pathway in MCF-7 cells. Thus, FSE may have therapeutic potential for controlling breast cancer invasiveness.
Keywords
MMP-9; NF-${\kappa}B$; Invasion; MCF-7 breast carcinoma cells;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Kim, J.M., Yun Choi, H.S. Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica. Arch Pharm Res. 31(7):886-890, 2008.   DOI
2 Tang, Y.P., Zhu, H.X., Duan, J.A. Two new isoflavone triglycosides from the small branches of Sophora japonica a. J Asian Nat Prod Res. 10(1-2):65-70, 2008.   DOI   ScienceOn
3 Tang, Y., Yang, R., Duan, J.A., Shang, E., Su, S., Zhu, M.,Qian, D. Isoflavone tetraglycosides from Sophora japonica Leaves.J Nat Prod. 71(3):448-450, 2008.   DOI   ScienceOn
4 Oya, M., Ohtsubo, M., Takayanagi, A., Tachibana, M., Shimizu, N., Murai, M. Constituitive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells. Oncogene 20(29):3888-3896, 2001.   DOI   ScienceOn
5 Figueroa, Y.G., Chan, A.K., Ibrahim, R., Tang, Y., Burow, M.E., Alam, J., Scandurro, A.B., Beckman, B.S. NF-kappaB plays a key role in hypoxia-inducible factor-1 regulated erythropoietin gene expression. Exp. Hematol. 30(12):1419-1427, 2002.   DOI   ScienceOn
6 Block, K.I., GyllenhaaI, C., Tripathy, D., Freels, S., Mead, M.N., Block, P.B., Steinrnann, W.C., Newman, R.A., Shoham, J. Survival impact of integrative cancer care in advanced metastatic breast canccr. Breast J. 15(4):357-366, 2009.   DOI   ScienceOn
7 eyaert, R., Heyninck, K., Van Huffel, S. A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappaB-dependent gene expression and apoptosis. Biochem. Pharmacol. 60(8):1143-1151, 2000.   DOI   ScienceOn
8 Edwards, B.K., Brown, M.L., Winga P.A., Howe, H.L.,Ward, E., Ries, L.A., Schrag, D., Jamison, P.M., Jemal, A., Wu, X.C., Friedrnan, C., Harlan, L., Warren, J., Anderson, R.N., Pickle, L.W. Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment. J. Natl. Cancer Inst. 97(19):1407-1427, 2005.   DOI   ScienceOn
9 Park, S., Bae, J., Nam, B.H., Yoo, K.Y. Aetiology of cancer in asia. Asian Pac. J. Cancer. Prev. 9(3):371-380, 2008.
10 Gupta, G.P., Minn, A.J., Kang, Y., Siegel, P.M., Serganova, I., Cordon-Cardo, C., Olshen, A.B., Gerald, W.L., Massague, J. Identifying site-specific metastasis genes and functions. Cold Spring Harb. Syrnp. Quant. BioI. 70: 149-158, 2005.   DOI   ScienceOn
11 Cavallaro, U., Christofori, G. Cell adhesion in tumor invasion and metastasis: Loss of the glue is not enough Biochim. Biophys. Acta. 1552(1):39-45, 2001.
12 문구, 정병학, 김병주, 암 동성의 결합치료. 원광대학교 출판국. 1: 118-119, 1999.
13 Woessner, J.F., Nagase, H. MMP and TIMPs. Newyork, Oxford Univ Press, 1: 253-256, 2000.
14 Inomara, S., Matsunaga, Y., Amano, S., Nishiyama, T. Possible involvement of gelatinases in basal membrane damage and Wrinkle formation in chronicall UVB-exposed hairless mouse. J.Inv. Derm. pp 120-134, 2003.
15 Rha, S.Y., Kim, S.J., Chung, H.C., Kim, J.H., Roh, J.K., Lee, K.S., Kim, B.S. Expression of Matrix-metalloproteinase-9 (MMP-9) in breast cancer. J. Kor. Cancer 28(2):247-252, 1996.
16 Schwartz, S.A., Hernandez, S.A., Mark, E.B. The role of NF-kappaB/ IkappaB IkappaB proteins in cancer: implications for novel treatment strategies. Surg. Oncol. 8(3):143-153, 1999.   DOI   ScienceOn
17 Kim, B.H., Chung, E.Y., Min, B.K., Lee, S.H., Kim, M.K.,Min, K.R., Kim, Y. Anti-inflammatory action of legume isoflavonoid sophoricoside through inhibition on cyclooxygenase-2 activity. Planta Med. 69(5):474-476, 2003.   DOI   ScienceOn
18 Korean Breast Cancer Society Policy Committee. Breast Cancer Facts & Figures 2006-2008. Seoul, Korean Breast Cancer Society, 2008.
19 송바다, 김순례, 김성훈, 신용철, 고성균. Butein에 의한 MCF-7 유방암 세포의 세포사별에 의한 항암효과. 동의생리병리학회지 24: 385-389, 2010.
20 Stetler-Stevenson, W.G. Type IV collagenases in tumor invasion and metastasis. Cancer Metast Rev 9: 289-303, 1990.   DOI   ScienceOn
21 National Cancer Information Center. National Cancer Statistics 2008. Available at: http://www.cancer.go.kr [accessed on 15 December 2010].
22 Ramos-DeSimone, N., Hahn-Dantona, E., Sipley, J., Nagase, H., French, D.L., Quigley, J.P. Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion. J Biol Chem 274: 13066-13076, 1999.   DOI   ScienceOn
23 Iwata, H., Kobayashi, S., Iwase, H., Masaoka, A., Fujimoto, N., Okada, Y. Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinomas. Jpn J Cancer Res 87: 602-611, 1996.   DOI
24 Liotta, L.A., Steeg, P.S., Stetler-Stevenson, W.G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64: 327-336, 1991.   DOI   ScienceOn
25 Lee, K.S., Shin, M.K. Theen cyclopedia of oriental herbal medicine. Jungdam, Seoul, Korea. pp 381-383, 1997.
26 Branen, A.L. Toxicology and biochemistry of butylated hydroxy anisol and butylated hydroxytoluene. JAmOilChemSoc 52: 59-63, 1975.
27 신민교. 임상본초학, 서울, 영림사, p 489, 2002.
28 Kite, G.C., Veitch, N.C., Boalch, M.E., Lewis, G.P., Leon, C.J., Simmonds, M.S. Flavonol tetraglycosides from fruits of Styphnolobium japonicum (Leguminosae) and the authentication of Fructus Sophorae and Flos Sophorae. Phytochemistry 70(6):785-794, 2009.   DOI   ScienceOn
29 Jung, C.H., Zhou, S., Ding, G.X., Kim, J.H., Hong, M.H., Shin, Y.C., Kim, G.J., Ko, S.G. Antihyperglycemic activity of herb extracts on streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem. 70(10):2556-2559, 2006.   DOI   ScienceOn
30 Davies, B., Miles, D.W., Happerfield, L.C., Naylor, M.S., Bobrow, L.G., Rubens, R.D., et al. Activity of type IV collagenases in benign and malignant breast disease. Br J Cancer 67: 1126-1131, 1993.   DOI   ScienceOn