Effect of Phaseolus angularis Seed on Experimental Cellular Model of Nonalcoholic Fatty Liver Disease
![]() |
Jang, Yeong Suk
(School of Korean Medicine, Korean Medicine Hospital, Pusan National University)
Seo, Ji Yun (School of Korean Medicine, Korean Medicine Hospital, Pusan National University) Kwun, Min Jung (School of Korean Medicine, Korean Medicine Hospital, Pusan National University) Kwon, Jung Nam (School of Korean Medicine, Korean Medicine Hospital, Pusan National University) Lee, In (School of Korean Medicine, Korean Medicine Hospital, Pusan National University) Hong, Jin Woo (School of Korean Medicine, Korean Medicine Hospital, Pusan National University) Kim, So Yeon (School of Korean Medicine, Korean Medicine Hospital, Pusan National University) Choi, Jun Yong (School of Korean Medicine, Korean Medicine Hospital, Pusan National University) Park, Seong Ha (School of Korean Medicine, Korean Medicine Hospital, Pusan National University) Joo, Myungsoo (School of Korean Medicine, Korean Medicine Hospital, Pusan National University) Han, Chang Woo (School of Korean Medicine, Korean Medicine Hospital, Pusan National University) |
1 | Pettinelli, P., Obregon, A.M., Videla, L.A. Molecular mechanisms of steatosis in nonalcoholic fatty liver disease. Nutr Hosp 26(3):441-450, 2011. |
2 | Repa, J.J., Liang, G., Ou, J., Bashmakov, Y., Lobaccaro, J.M., Shimomura, I., Shan, B., Brown, M.S., Goldstein, J.L., Mangelsdorf, D.J. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 14(22):2819-2830, 2000. DOI ScienceOn |
3 | Viollet, B., Foretz, M., Guigas, B., Horman, S., Dentin, R., Bertrand, L., Hue, L., Andreelli, F. Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol 574(Pt1):41-53, 2006. DOI ScienceOn |
4 | Kohjima, M., Higuchi, N., Kato, M., Kotoh, K., Yoshimoto, T., Fujino, T., Yada, M., Yada, R., Harada, N., Enjoji, M., Takayanagi, R., Nakamuta, M. SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease. Int J Mol Med 21(4):507-511, 2008. |
5 | Zhang, Y., Breevoort, S.R., Angdisen, J., Fu, M., Schmidt, D.R., Holmstrom, S.R., Kliewer, S.A., Mangelsdorf, D.J., Schulman, I.G. Liver LXRalpha expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest 122(5):1688-1699, 2012. DOI ScienceOn |
6 | Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., Musi, N., Hirshman, M.F., Goodyear, L.J., Moller, D.E. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108(8):1167-1174, 2001. DOI ScienceOn |
7 | Masuoka, H.C., Chalasani, N. Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals. Ann N Y Acad Sci 1281: 106-122, 2013. DOI ScienceOn |
8 | Falck-Ytter, Y., Younossi, Z.M., Marchesini, G., McCullough, A.J. Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis 21(1):17-26, 2001. DOI ScienceOn |
9 | Daniel, S., Ben-Menachem, T., Vasudevan, G., Ma, C.K., Blumenkehl, M. Prospective evaluation of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patients. Am J Gastroenterol 94(10):3010-3014, 1999. DOI ScienceOn |
10 | Bugianesi, E., Leone, N., Vanni, E., Marchesini, G., Brunello, F., Carucci, P., Musso, A., De Paolis, P., Capussotti, L., Salizzoni, M., Rizzetto, M. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 123(1):134-140, 2002. DOI ScienceOn |
11 | Ibrahim, M.A., Kelleni, M., Geddawy, A. Nonalcoholic fatty liver disease: current and potential therapies. Life Sci 92(2):114-118, 2013. DOI ScienceOn |
12 | Wu, J.N. An illustrated Chinese materia medica. New York, N.Y., Oxford University Press. p 474, 2005. |
13 | 허준. 동의보감. 서울, 법인문화사, p 745, 1999. |
14 | Clarke, P.R., Hardie, D.G. Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. EMBO J 9(8):2439-2446, 1990. |
15 | Lin, H.Z., Yang, S.Q., Chuckaree, C., Kuhajda, F., Ronnet, G., Diehl, A.M. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med 6(9):998-1003, 2000. DOI ScienceOn |
16 | Shi, K.Q., Fan, Y.C., Liu, W.Y., Li, L.F., Chen, Y.P., Zheng, M.H. Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis. Mol Biol Rep 39(10):9715-9722, 2012. DOI |
17 | Muoio, D.M., Seefeld, K., Witters, L.A., Coleman, R.A. AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J 338(Pt3):783-791, 1999. DOI ScienceOn |
18 | Yu, T., Ahn, H.M., Shen, T., Yoon, K., Jang, H.J., Lee, Y.J., Yang, H.M., Kim, J.H., Kim, C., Han, M.H., Cha, S.H., Kim, T.W., Kim, S.Y., Lee, J., Cho, J.Y. Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans. J Ethnopharmacol 137(3):1197-1206, 2011. DOI ScienceOn |
19 | Nakaya, K., Nabata, Y., Ichiyanagi, T., An, W.W. Stimulation of dendritic cell maturation and induction of apoptosis in leukemia cells by a heat-stable extract from azuki bean (Vigna angularis), a promising immunopotentiating food and dietary supplement for cancer prevention. Asian Pac J Cancer Prev 13(2):607-611, 2012. DOI ScienceOn |
20 | Hori, Y., Sato, S., Hatai, A. Antibacterial activity of plant extracts from azuki beans (Vigna angularis) in vitro. Phytother Res 20(2):162-164, 2006. DOI ScienceOn |
21 | Itoh, T., Kobayashi, M., Horio, F., Furuichi, Y. Hypoglycemic effect of hot-water extract of adzuki (Vigna angularis) in spontaneously diabetic KK-A(y) mice. Nutrition 25(2):134-141, 2009. DOI ScienceOn |
22 | Mukai, Y., Sato, S. Polyphenol-containing azuki bean (Vigna angularis) extract attenuates blood pressure elevation and modulates nitric oxide synthase and caveolin-1 expressions in rats with hypertension. Nutr Metab Cardiovasc Dis 19(7):491-497, 2009. DOI ScienceOn |
23 | Ha, S.K., Kim, J., Chae, C. Role of AMP-activated protein kinase and adiponectin during development of hepatic steatosis in high-fat diet-induced obesity in rats. J Comp Pathol 145(1):88-94, 2011. DOI ScienceOn |
24 | Laffitte, B.A., Chao, L.C., Li, J., Walczak, R., Hummasti, S., Joseph, S.B., Castrillo, A., Wilpitz, D.C., Mangelsdorf, D.J., Collins, J.L., Saez, E., Tontonoz, P. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci U S A. 100(9):5419-5424, 2003. DOI ScienceOn |
25 | Lee, E.K., Park, Y.J. Metabolic regulation of nuclear receptors. EnM 23(3):155-164, 2008. |
26 | Long, Y.C., Zierath, J.R. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116(7):1776-1783, 2006. DOI ScienceOn |
27 | Cao, J., Dai, D.L., Yao, L., Yu, H.H., Ning, B., Zhang, Q., Chen, J., Cheng, W.H., Shen, W., Yang, Z.X. Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway. Mol Cell Biochem 364(1-2):115-129, 2012. DOI |
28 | Itoh, T., Furuichi, Y. Lowering serum cholesterol level by feeding a 40% ethanol-eluted fraction from HP-20 resin treated with hot water extract of adzuki beans (Vigna angularis) to rats fed a high-fat cholesterol diet. Nutrition 25(3):318-321, 2009. DOI ScienceOn |
29 | Liu, J., Li, Y.M., Chen, S.H., Li, W.P. An in vitro hepatic steatosis cell model for study of non-alcoholic fatty liver disease. Zhejiang Da Xue Xue Bao Yi Xue Ban 38(6):626-629, 2009. |
30 | Kim, D.S., Jeong, S.K., Kim, H.R., Kim, D.S., Chae, S.W., Chae, H.J. Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells. Immunopharmacol Immunotoxicol 32(2):251-257, 2010. DOI ScienceOn |
31 | Browning, J.D., Horton, J.D. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114(2):147-152, 2004. DOI |
32 | Foretz, M., Ancellin, N., Andreelli, F., Saintillan, Y., Grondin, P., Kahn, A., Thorens, B., Vaulont, S., Viollet, B. Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes 54(5):1331-1339, 2005. DOI ScienceOn |
33 | Kawaguchi, T., Osatomi, K., Yamashita, H., Kabashima, T., Uyeda, K. Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. J Biol Chem 277(6):3829-3835, 2002. DOI ScienceOn |
34 | Munday, M.R., Campbell, D.G., Carling, D., Hardie, D.G. Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. Eur J Biochem 175(2):331-338, 1988. DOI ScienceOn |
35 | Chuthan Sourianarayanane A, Pagadala MR, Kirwan JP. Management of non-alcoholic fatty liver disease. Minerva Gastroenterol Dietol 59(1):69-87, 2013. |
36 | Yao, Y., Cheng, X., Wang, S., Wang, L., Ren, G. Influence of altitudinal variation on the antioxidant and antidiabetic potential of azuki bean (Vigna angularis). Int J Food Sci Nutr 63(1):117-124, 2012. DOI ScienceOn |
![]() |