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Anti-hyperlipidemic Effect of Shiitake Mushroom Extract in Hyperlipidemic Rats Induced by Poloxamer-407  

Kim, Gye Yeop (Department of Physical Therapy, Dongshin University)
Jung, Hun Woo (Department of Korean Medicine, Dongshin University)
Kim, Eun Jung (Department of Physical Therapy, Nambu University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.27, no.4, 2013 , pp. 409-415 More about this Journal
Abstract
We attempted to determine the action target of Shiitake mushroom extract with a known anti-hyperlipidemic effect in poloxamer(P) 407-induced hyperlipidemia model. We investigated the anti-hyperlipidemic effects of the water extract from Shiitake mushroom on the progress of high fat diet for 4 weeks. Experimental rats were divided into 5 different experimental groups including an normal group (normal diet; n=10), control group (hyperlipidemia; n=10), Experimental group I (hyperlipidemic rats treated with Shiitake mushroom extract (100 mg/kg, PO), n=10), Experimental group II (hyperlipidemic rats treated with Shiitake mushroom extract (300 mg/kg, PO), n=10), and Experimental group III (hyperlipidemic rats treated with Shiitake mushroom extract (500 mg/kg, PO), n=10). It is to analysis changes in body weight, visceral fat weight, blood lipid profiles, HMG-CoA reductase and histological findings. Body weight and epididymal fat weight was not significantly change in experimental groups (p>0.05). The level of total cholesterol, TG, arthrogenic index, and HMG-CoA reductase were significantly lower in experimental groups than control group (p<0.05). These results suggested that the Shiitake mushroom extract administration may act by inhibitory the release of cholesterol related factors and HMG-CoA from the hepatocyte without liver and kidney cell damage in hyperlipidemia rats.
Keywords
HMG-CoA reductase; Hyperlipidemia; Shiitake mushroom;
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