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Effects of Sokmyong-tang on Ferric Chloride-induced Carotid Injury and Thrombosis in a Rat Model  

Heo, Eun Jung (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Lee, In Sun (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Kang, Hyung Won (Department of Neuropsychiatry, College of Oriental Medicine, Won-Kwang University)
Jeon, Won Kyung (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.26, no.5, 2012 , pp. 732-737 More about this Journal
Abstract
The aim of this study is examine the protection effect for artery and antithrombotic effect of Sokmyong-tang(SMT; xuming-tang) on carotid artery thrombosis in a rat model. Thirty minutes before $FeCl_3$ treatment, SD rats were intraperitoneal injected with SMT. We tested the effects of SMT on time to occlusion (TTO) in thrombosis model by induced $FeCl_3$ using the laser Doppler flow meter and accessed thrombus weight (TW) inhibition and measured collagen fibers in the vessel after injury using Masson's trichrome stain. SMT(100 mg/kg, i.p.) showed significantly delayed TTO ($13.17{\pm}1.33$ min, P < 0.001) compared to vehicle control group ($8.63{\pm}0.92$ min) and inhibiting effect on TW with $0.72{\pm}0.02$ mg/mm (P < 0.05). In addition, SMT prevented collagen fibres damage in injured vessel ($22.24{\pm}4.48%$, P < 0.001). These results provide experimental evidence for SMT can be used to prevent vascular injury and thrombosis such as hypertension, arteriosclerosis, and so on.
Keywords
sokmyong-tang; herbal medicine; carotid artery thrombosis model; thrombosis; vascular injury;
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