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Antidiabetic Effects of Water Extract from Taraxacum coreanum Nakai in type II Diabetic Mice  

Oh, Chan Ho (Department of Food Science & Biotechnology, College of Food Science, Woosuk University)
Shin, Nam Sik (Nimmaeul Corporation LTD.)
Kwan, Jin (Department of Prosthetics & Orthotics, Korea National College of Rehabilitation & Welfare)
Lee, Kwang Gyu (Department of Oriental Pathology, College of Oriental Medicine, Woosuk University)
Lee, Sang Ryong (Department of Meridian & Acupoint, College of Oriental Medicine, Woosuk University)
Lee, Chang Hyun (Department of Anatomy, College of Oriental Medicine, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.26, no.5, 2012 , pp. 707-713 More about this Journal
Abstract
Taraxacum coreanum Nakai (TM) has been investigated for its antidiabetic activity in streptozotocin induced diabetic animals, but few studies have been conducted to evaluate its efficacy for treatment of type II diabetic mice. This study was designed to evaluate the efficacy of the water extracts of TM for the treatment of type II diabetes. Twenty four mice(C57BLKS/J Iar $-+Lepr^{db}/+Lepr^{db}$) with type II diabetes were randomly assigned either to a experimental group A (leaves extraction of TM), experimental group B(roots extraction of TM), experimental group C(leaves, roots and flowers extraction of TM) or control group. Water extracts of TM were ingested for 10 weeks. The changes of body weight, level of blood glucose, numerical change of insulin-immunoreactive cells and level of blood insulin were measured after treatment of water extracts of TM. A reduction of the blood glucose level after treatment of TM was observed in all the experimental groups. Especially, experimental C group showed significant reduction of blood glucose level compared with control group. Experimental C group induced an increase the level of blood insulin and density of insulin immunoreactive cells after treatment of TM. These results show that water extracts of TM can improve the severity in type II diabetic mice.
Keywords
taraxacum coreanum nakai(TM); diabetes; insulin; blood glucose; immunohistochemistry;
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