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Effect of Wogonin on Hydrogen Peroxide Production in Polyinosinic-Polycytidylic acid-induced Human Neuroblastoma SH-SY5Y Cells  

Park, Wan-Su (Department of Pathology, College of Oriental Medicine, Gachon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.26, no.4, 2012 , pp. 491-496 More about this Journal
Abstract
The purpose of this study is to investigate the modulatory effect of wogonin on hydrogen peroxide production in human blastoma SH-SY5Y cells induced by the synthetic analog of double-stranded RNA [polyinosinic-polycytidylic acid]. Hydrogen peroxide production was measured by dihydrorhodamine 123 (DHR) assay. Wogonin significantly inhibited the polyinosinic-polycytidylic acid (PIC)-induced production of hydrogen peroxide for 0.5, 2, 12, 18, and 24 hr incubation at the concentrations of 10, 25, and 50 ${\mu}M$ in SH-SY5Y (P < 0.05) in dose dependent manner. These results suggest that wogonin has neuroprotective property related with its inhibition of hydrogen peroxide production in PIC-induced neuronal cells.
Keywords
Wogonin; Neuronal cells; DsRNA; Hydrogen peroxide; Anti-oxidative;
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Times Cited By KSCI : 6  (Citation Analysis)
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