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Effect of Rehmannia glutinosa on Phosphorylation of ERK and CREB in Acute Cocaine-treated Rats  

Kwon, Ki-Won (Department of Physiology, College of Oriental Medicine, Daegu Haany University)
Jang, Eun-Young (Department of Physiology, College of Oriental Medicine, Daegu Haany University)
Im, Chae-Kwang (Department of Physiology, College of Oriental Medicine, Daegu Haany University)
Yang, Chae-Ha (Department of Physiology, College of Oriental Medicine, Daegu Haany University)
Kim, Kwang-Joong (Department of Physiology, College of Oriental Medicine, Daegu Haany University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.26, no.3, 2012 , pp. 281-286 More about this Journal
Abstract
The present study was designed to investigate the effect of Rehmannia glutinosa on phosphorylation of extracellular signal-regulated kinase(ERK) and cAMP response element-binding protein(CREB) in the acute cocaine-treated rats. Rats orally received vehicle or extract of Rehmannia glutinosa 1 h prior to saline (1 ml/kg, i.p.) or cocaine hydrochloride (20 mg/kg, i.p.) treatment. Rats were sacrificed 15 min after a single intraperitoneal injection of saline or cocaine. Rehmannia glutinosa at dose of 50 mg/kg significantly decreased phosphorylation of ERK, CREB and Elk-1 in the nucleus accumbens and striatum of the cocaine-treated rat brain by immunocytochemistry. These results suggest that Rehmannia glutinosa may contribute to the effects of cocaine on gene expression and on behaviors.
Keywords
Rehmannia glutinosa; acute cocaine; ERK; CREB; striatum; nucleus accumbens;
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