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Study on Sleeping Behaviors of The Combined-Preparation of Crude Drugs -on The $Well^{TM}$ Preparation-  

Pang, Jinye (College of Pharmacy, Woosuk University)
Lee, Mi-Kyung (College of Pharmacy, Woosuk University)
Seo, Seung-Young (College of Pharmacy, Woosuk University)
Jeon, Hoon (College of Pharmacy, Woosuk University)
Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Oh, Ki-Wan (College of Pharmacy, Chungbuk National University)
Cho, Hyoung-Kwon (Hanpoong Pharmaceutical Company)
Eun, Jae-Soon (College of Pharmacy, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.25, no.6, 2011 , pp. 996-999 More about this Journal
Abstract
This experiment was performed to investigate whether the combined-preparation of crude drugs (The $Well^{TM}$ Preparation, TW), has hypnotic effects and/or enhances pentobarbital-induced sleep behaviors. TW was mixed with water extracts of Ginseng Radix red, Germinated brown rice, cultured mountain ginseng, and 50% ethanol extracts of Longanae Arillus, Nelumbinis Folium and Chrysanthemi Flos. TW (100 mg/kg, p.o.) reduced sleep onset and prolonged sleep time induced by pentobarbital similar to muscimol (0.2 ${\mu}M$), a $GABA_A$ receptor agonist. Also, TW (2 ${\mu}g$/ml) and pentobarbital (2.5 ${\mu}M$) did not affect the chloride influx in primary cultured cerebellar granule cells, respectively, but the combined-treatment of TW (2 ${\mu}g$/ml) and pentobarbital (2.5 ${\mu}M$) increased the chloride influx onto the cells. In conclusion, TW augments pentobarbital-induced sleep behaviors; these effects may result from chloride channel activation.
Keywords
ginseng radix red; germinated brown rice; cultured mountain ginseng; longanae arillus; nelumbinis folium; chrysanthemi flos; sleep latency; sleep time; chloride ion;
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