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Anti-allergic Activity of Dojuk-San Ethanol Extract  

Sung, Sun-Heui (Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Su-Kyoung (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Wonkwang University)
Kang, Ok-Hwa (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University)
Kwon, Dong-Yeul (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University)
Chong, Myong-Soo (Department of Preventive Medicine, College of Oriental Medicine & Research Center of Traditional Korean Medicine, Wonkwang University)
Lee, Ki-Nam (Department of Preventive Medicine, College of Oriental Medicine & Research Center of Traditional Korean Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.25, no.3, 2011 , pp. 438-444 More about this Journal
Abstract
Dojuk-San is known to be effective for treating a urinary diseases and stomatitis. However, its effects on the bone marrow-derived mast cell(BMMC) mediated allergy and inflammation mechanism remain unknown. In this study, the biological effects of Dojuk-San ethanol extract(DJS) were evaluated while focusing on its effects on the allergic mediator in phorbol 12-myristate 13-acetate(PMA) plus calcium ionophore A23187(A23187)-stimulated BMMCs. An investigation was also conducted to determine its effects on the production of several allergic mediators including interleukin-6(IL-6), prostaglandin D2($PGD_2$), leukotrieneC4(LTC4) and ${\beta}$-Hexosaminidase(${\beta}$-Hex). The results revealed that DJS inhibited the PMA plus A23187 induced production of IL-6, PGD2, LTC4 and ${\beta}$-Hex. Taken together, these findings indicate that DJS has the potential using in the treatment of allergy.
Keywords
Dojuk-San; bone marrow-derived mast cell(BMMC); IL-6; $PGD_2$; LTC4; ${\beta}$-Hexosaminidase;
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