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Comparison of the Anti-inflammatory Effects of Water Fermented and Ethanol Fermented Extracts from Rhei Radix et Rhizoma  

Kim, Nan-Young (Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
Kim, Hae-Ja (Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Joo-Hee (Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Eun-Kyoung (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University)
Kang, Ok-Hwa (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University)
Kwon, Dong-Yeul (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University)
So, Hong-Seob (Department of Microbiology, School of Medicine, Wonkwang University)
Lee, Ki-Nam (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University)
Chong, Myong-Soo (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.25, no.2, 2011 , pp. 227-233 More about this Journal
Abstract
Water Fermented and Ethanol Fermented Extracts from Rhei Radix et Rhizoma exhibit potent anti-inflammatory activity with an unknown mechanism. To elucidate the molecular mechanisms of W-FR and E-FR on pharmacological and biochemical actions in inflammation, we examined the effect of W-FR and E-FR on pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated macrophages. The investigation focused on whether FR inhibited nitric oxide (NO), tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-6 (IL-6) and the expressions of iNOS, COX-2 in LPS-stimulated RAW 264.7 cells. We found that FR inhibited LPS-induced NO, TNF-${\alpha}$ and IL-6 productions as well as the expressions of iNOS and COX-2. These results suggest that W-FR and E-FR have inhibitory effects on LPS-induced TNF-${\alpha}$, NO, and IL-6 production, as well as the expressions of iNOS and COX-2 in the murine macrophage.
Keywords
Rhei radix et rhizoma; fermentation; anti-inflammation;
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