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Antioxidant Effects and Anti-inflammation Effects of Lophatheri Herba Water Extracts Via Reducing iNOS Synthesis Induced by LPS in RAW 264.7 Cell  

Hwang, Sung-Yeoun (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Lee, Sung-Won (Department of Meridian & Acupoint, College of Oriental Medicine, Wonkwang University)
Kwon, Kang-Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Choi, Won-Jong (Department of Meridian & Acupoint, College of Oriental Medicine, Wonkwang University)
Kim, Jae-Hyo (Department of Meridian & Acupoint, College of Oriental Medicine, Wonkwang University)
Ahn, Seong-Hun (Department of Meridian & Acupoint, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.24, no.6, 2010 , pp. 976-982 More about this Journal
Abstract
We studied to know the anti-inflammation effect on water extracts of Lophatheri Herba which was growing in every places in our country. We objected free radical scanvenger effect and nitrite eliminate effect of the Lophatheri Herba water extracts, and the cell viabillity, the effects of Lophatheri Herba water extracts on NO production, iNOS synthesis induced by LPS. Free radical scavenger effects were $27.91{\pm}0.12%$, $38.96{\pm}0.10%$, $46.22{\pm}0.15%$ depend on 0.5, 1.0, 2.0 mg/ml each dose of Lophatheri Herba water extracts. Nitrite eliminate effects were $9.86{\pm}0.3%$, $80.61{\pm}0.23%$, $97.62{\pm}0.56%$ in 0.1, 1.0, 2.0 mg/ml Lophatheri Herba water extracts on pH 1.2. NO production and iNOS synthesis induced by LPS were reduced in RAW 264.7 cell by Lophatheri Herba water extracts. As the above results, Lophatheri Herba water extracts have anti-inflammation effects via NO production decrease, iNOS synthesis decrease mechanism. So Lophatheri Herba water extracts will be used as the protection or treatment in chronic inflammation desease like a asthma, stomatitis etc.
Keywords
lophatheri herba; nitrite oxide; iNOS synthesis; anti-inflammation effect;
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