Browse > Article

Study of Dansameum on the Pharmacological Effect  

Eun, Jae-Soon (Department of Pharmacy, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.24, no.5, 2010 , pp. 827-830 More about this Journal
Abstract
The purpose of this research was to investigate the pharmacological effects of Dansameum (DSE) water extract which is composed with Salviae Radix, Santali Lignum and Amomi Semen. DSE was administered orally at the concentartion of 100 and 500 mg/kg. DSE decreased the writhing syndrome induced by acetic acid and the permeability of evans blue into peritoneal cavity. Also, DSE inhibited the production of nitric oxide from murine macrophages. Futhermore, DSE protected the liver injury induced by galactosamine in vitro system and $CCl_4$ in vivo system. These results suggest that DSE has a diverse effects such as analgesic action, inflammatory action and liver protective action.
Keywords
Dansameum; writhing syndrome; galactosamine; $CCl_4$;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Chor, J.S., Yu, J., Chan, K.K., Go, Y.Y., Sung, J.J. Stephania tetrandra prevents and regresses liver fibrosis induced by carbon tetrachloride in rats. J. Gastroenterol. Hepatol., 24(5):853-859, 2009.   DOI   ScienceOn
2 Park, E.J., Zhao, Y.Z., Na, M., Bae, K., Kim, Y.H., Lee, B.H., Sohn, D.H. Protective effects of honokiol and magnolol on tertiary butyl hydroperoxide- or D-galactosamine-induced toxicity in rat primary hepatocytes. Planta Med. 69(1):33-37, 2003.   DOI   ScienceOn
3 Iga, T., Sugiyama, Y., Yokota, M., Tomono, Y., Awazu, S., Hanano, M. Pharmacokinetic aspects of sulfobromophthalein transport in chronically carbon tetrachloride-intoxicated rats. Biochem. Pharmacol., 26(20):1867-1875, 1977.   DOI   ScienceOn
4 Ding, H., Huang, J.A., Tong, J., Yu, X., Yu, J.P. Influence of Kupffer cells on hepatic signal transduction as demonstrated by second messengers and nuclear transcription factors. World J. Gastroenterol., 9(11):2519-2522, 2003.   DOI
5 Cherkasov, V.S., Nemchenko, N.S. [Determination of the activity of blood serum alanine- and aspartate aminotransferases (ALT, AST) in various forms of hearing disorders]. Zh Ushn Nos Gorl Bolezn. (2):23-26, 1978.
6 Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J. Immunol. methods. 65: 55, 1983.
7 Kotnic, V. and Fleischmann, W.R.Jr. A simple and rapid method to determine hematopoietic growth factor activity. J. Immunol. methods. 129: 23, 1990.   DOI   ScienceOn
8 Whittle, B.A. The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics. Brit. J. Pharmacol. 22: 246-253, 1964.
9 Reitman, S., Frankel, S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol., 28(1):56-63, 1957.   DOI
10 김창민 外. 完譯 中藥大辭典 5권. 서울, 도서출판 정담, p 1983, 1999.
11 陳修園. 醫學全書.時方歌括. 北京, 中國中醫藥出版社, p 956, 2006.
12 Shimomura, K., Fukushima, T. A new method for the rapid determination of azovan blue leaked into the skin. J. Pharm. Pharmacol. 24(10):837-838, 1972.   DOI
13 Rockett, K.A., Awburn, M.M., Cowden, W.B. and Clark, I.A. Killing of Plasmodium faciparum in vitro by nitric oxide derivatives. Infec. Immunity, 59(9):3280, 1991.
14 Lee, W.Y., Cheung, C.C., Liu, K.W., Fung, K.P., Wong, J., Lai, P.B., Yeung, J.H. Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells. J. Nat. Prod., 73(5):854-859, 2010.   DOI   ScienceOn
15 Cha Jae-Young, Ha Se-Eun, Sim Seon-Mi, Park Jong-Kun, Chung Yeon-Ok, Kim Hyun-Joong, Park Nou-Bog. Antimicrobial Effects of Ethanol Extracts of Korea Endemic Herb Plants, Journal of Life Science 18(2):228-233, 2008.   과학기술학회마을   DOI   ScienceOn
16 김창민 外. 完譯 中藥大辭典, 서울, 도서출판 정담, p 866, 1999.
17 최선미, 최승훈, 안규석. Study on Antitumor and Apoptosis - Inducing Effects of Salviae miltiorrhizae Radix, 14(2):22-47, 2000.
18 손윤희, 조현정, 장현욱, 손건호, 남경수. 단삼 분획추출물의 암예방 효과, Journal of Life Science, 16(3):369-374, 2006.   과학기술학회마을   DOI   ScienceOn
19 Jae Soon Eun, Jong Pil Lim, Yi Kyu Park, Dong Seong Choi and Moon Seng Ahn. Hepatoprotective Activity of Salviae miltiorrhizae Radix Extract, 22(2):95-100, 1991.
20 Park, E.J., Zhao, Y.Z., Kim, Y.C., Sohn, D.H. Preventive effects of a purified extract isolated from Salvia miltiorrhiza enriched with tanshinone I, tanshinone IIA and cryptotanshinone on hepatocyte injury in vitro and in vivo. Food Chem. Toxicol., 47(11):2742-2748, 2009.   DOI   ScienceOn
21 江克明 外. 簡明方劑辭典. 上海, 上海科學技術出版社, p 221, 1989.
22 Clawson, G.A. Mechanisms of carbon tetrachloride hepatotoxicity. Pathol. Immunopathol. Res., 8(2):104-112, 1989.   DOI   ScienceOn
23 Matsushita, K., Morrell, C.N., Cambien, B., Yang, S.X., Yamakuchi, M., Bao, C., Hara, M.R., Quick, R.A., Cao, W., O'Rourke, B., Lowenstein, J.M., Pevsner, J., Wagner, D.D., Lowenstein, C.J. Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor. Cell, 115(2):139-150, 2003.   DOI   ScienceOn