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Anti-inflammatory Effects of Effective Microorganism Fermentation Substance on Atopic Dermatitis-like NC/Nga Mouse Model  

Mok, Ji-Ye (Jeonju University Atopy & Health Research Institute)
Jeong, Seung-Il (Jeonju Biomaterials Institute)
Cho, Jung-Keun (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University)
Choi, Ji-Won (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University)
Nam, Sang-Yun (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University)
Chang, Won-Ghil (School of Alternative Medicine & Health Science, College of Alternative Medicine, Jeonju University)
Moon, Byung-Eun (Evermiracle Research Institute)
Park, Kwang-Hyun (Department of Biochemistry, Chonbuk National University Medical School)
Jang, Seon-Il (Jeonju University Atopy & Health Research Institute)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.24, no.2, 2010 , pp. 258-265 More about this Journal
Abstract
Atopic dermatitis (AD) is a chronically relapsing pruritic inflammatory skin disease. To find new anti-inflammatory products for skin inflammatory disease such as AD and contact dermatitis, we produced the effective microorganism fermentation substance (EM-S) by fermentation of medicinal plants with effective microorganisms including photosynthetic bacteria, lactic acid bacteria and yeast, screened the effects of EM-S on NC/Nga model mice. Murine AD-like skin lesions were made by painting Dermatophagoides farinae (Df) extract. Topically applied EM-S significantly reduced clinical severity score, ear thickness and histological grade in AD-like NC/Nga mouse model by Df antigen sensitization. In addition, the serum IgE and Th2 chemokine levels (TARC/CCL17, MDC/CCL22 and CTACK/CCL27) were significantly reduced by EM-S. Futhermore, skin tissue expressions of Th2 chemokines were significantly reduced by EM-S. These results demonstrate that topical application of EM-S may be improve the AD-like skin lesion by suppressing IgE and Th2 chemokines.
Keywords
atopic dermatitis; Dermatophagoides farinae (Df); EM-S; IgE; Th2 chemokines;
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