Browse > Article

Effect of Ginseng-Berry Extract on the Improvement of Blood Microcirculation and Skin Brightness  

Kim, Jeong-Kee (Amorepacific Corporation R&D Center)
Kim, Byoung-Soo (College of Oriental Medicine Daejeon University)
Park, Chan-Woong (Amorepacific Corporation R&D Center)
Seo, Dai-Bang (Amorepacific Corporation R&D Center)
Yoo, Ho-Rhyong (College of Oriental Medicine Daejeon University)
Lee, Sang-Jun (Amorepacific Corporation R&D Center)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.24, no.1, 2010 , pp. 85-90 More about this Journal
Abstract
Several studies have demonstrated that ginseng-berry extract has several beneficial properties, including anti-inflammatory, antioxidant, and vasodilation properties. Ginseng-berry extract has also been shown to have the great potential against skin aging. Its beneficial mechanism against skin aging, however, has not been examined in detail. Also, the effects of ginseng-berry extract on microcirculation and skin cellular responses have not been investigated. Inhibition of skin microcirculation is the primary cause of many adverse biological effects, which is responsible for the skin aging and darkening. We investigated the beneficial effects of ginseng-berry extract on blood circulation, transcutaneous oxygen pressure in vivo model and also on skin microcirculation, cellular response and skin brightening effect in clinical trial. We found that oral administration of ginseng-berry extract markedly increased blood flow rate and transcutaneous $O_2$ pressure, but decreased transcutaneous $CO_2$ pressure. Also, it improved skin tone on cheeks, as is skin brighteness. These results suggest that ginseng-berry extract is a potent candidate for the treatment of skin aging and brightening by improving skin microcirculation.
Keywords
ginseng-berry; microcirculaation; transcutaneous gas pressure; brighteness;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Boldt, J. Clinical review. Hemodynamic monitoring in the intensive care unit. Critical Care, 6: 52-59, 2002.   DOI   ScienceOn
2 Kalus, U., Koscielny, J., Grigorov, A., Schaefer, E., Peil, H., Kiesewetter, H. Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered red vine leaves AS 195: a randomized, double-blind, placebo-controlled, crossover study. Drugs and RD. 5(2):63-71, 2004.   DOI   ScienceOn
3 Jeon, H.Y., Kim, J.K., Kim, W.G., Lee, S.J. Effects of Oral Epigallocatechin Gallate Supplementation on the Minimal Erythema Dose and UV-Induced Skin Damage. Skin Pharmacol Physiol. 22: 137-141, 2009.   DOI   ScienceOn
4 Furukawa, F., Kanehara, S., Harano, F., et al. Effects of adenosine 5'-monophosphate on epidermal turnover. Arch Dermatol Res. 300(9):485-493, 2008.   DOI   ScienceOn
5 Bongard, O., Bounameaux, H. Clinical investigation of skin microcirculation. Dermatology 186: 6-11, 1993.   DOI   ScienceOn
6 Katiyar, S.K., Elment, C.A. Green tea polyphenolic antioxidants and skin protection. Int. J. Oncol. 18: 1307-1313, 2001.
7 김선영, 안덕균, 박성규, 이진영, 김완기, 심영철, 이상준. 한방미용 제재의 hairless mouse model에서의 피부 광노화 억제 및 섬유아세포에서의 UVB 손상 저해 효과. 대한한의학회지 23(3):43-53, 2002.   과학기술학회마을
8 Cho, H.S., Kim, S., Lee, S.Y., Park, J.A., Kim, S.J., Chun, H.S. Protective effect of the green tea component, L-theanine on environmental toxins-induced neuronal cell death. Neurotoxicology 29(4):656-662, 2008.   DOI   ScienceOn
9 Wang, C.Z., Wu, J.A., McEntee, E., Yuan, C.S. Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatography. J. Agric. Food Chem. 54(6):2261-2266, 2006.   DOI   ScienceOn
10 채윤병, 이승일, 강인정, 이은미. 한방피부미용학 개요. 대한한방피부미용학회, 1(1):145-157, 2005.
11 Xie, J.T., Shao, Z.H., Vanden Hoek, T.L., et al. Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur. J. Pharmacol. 532(3):201-207, 2006.   DOI   ScienceOn
12 Yang, W.J., Yang, P.P. Literature survey on biomedical applications of thermography. Biomed. Mat. Engineer. 2: 7-18, 1992.
13 Attele, A.S., Zhou, Y.P., Xie, J.T., et al. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabete. 51(6):1851-1858, 2002.   DOI   ScienceOn
14 김은주, 안성연, 남개원. 적송엽함유 한방화장품이 인체 피부 노화에 미치는 영향 연구. 대한본초학회지 21(1):25-31, 2006.   과학기술학회마을
15 Wright, C.I., Croner, C.I., Draijer, R. Non-invasive method and stimuli for evaluating the skin's microcirculation. J. Pharmacol. Toxicol. Methods. 54: 1-25, 2006.   DOI   ScienceOn
16 黃霏莉. 미용중의학. 북경, 과학출판사, pp 79-89, 1999.
17 이상준. 피부 미용 효능을 갖는 신규 식이 천연 소재. Food Science and Industry. 40(4):10-18, 2007.
18 이숙경. 피부미용과 영양. 서울, 도서출판정담, pp 119-121, 2000.
19 Kang, T.H., Park, H.M., Kim, Y.B., Kim, H., Kim, N., Do, J.H., Kang, C., Cho, Y., Kim, S.Y. Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. J. Ethnopharmacol. 123(3):446-451, 2009.   DOI   ScienceOn
20 Karna, E., Miltyk, W., Wolczynski, S., Palka, J.A. The potential mechanism for glutamine-induced collagen biosynthesis in cultured human skin fibroblasts. Comp Biochem Physiol B Biochem Mol Biol. 130(1):23-32, 2001.   DOI   ScienceOn
21 Van Beekvelt, M.C., Colier, W.N., Wevers, R.A., Van Engelen, B.G. Performance of near-infrared spectroscopy in measuring local O2 consumption and blood flow in skeletal muscle. J. Applied Physiol. 90: 511-519, 2001.   DOI