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Anti-adipogencic Effect of Piper Nigrum Linne  

Jeong, Hong-Suk (Department of Internal Medicine, College of Korean Medicine, Dongguk University)
Jeong, Ji-Cheon (Department of Internal Medicine, College of Korean Medicine, Dongguk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.24, no.1, 2010 , pp. 118-123 More about this Journal
Abstract
Piper nigrum Linne has been used spice as well as herbal medicine in worldwide and has function of anti-oxidant, anti-inflammation, anti-cancer, bioavailability of drugs and etc. In this study, anti-adipogenic activity of Piper nigrum Linne extract and its constituent piperine were investigated in 3T3-L1 differentiation. Adipogenic effects and lipid accumulation in 3T3-L1 was measured by RT-PCR and Oil Red O staining assays respectively in stimulation of Piper nigrum Linne extract and piperine. Piper nigrum Linne and piperine reduced lipid accumulation in 3T3-L1 differentiation and expression of genes associated with adipogenesis such as PPAR${\gamma}$, adipsin, SERBP-1c and LPL. All of taken, anti-adipogenic mechanism of Piper nigrum Linne and piperine were related with regulation of SREBP-1c and PPAR${\gamma}$ expression.
Keywords
Piper nigrum Linne; piperine; adipogenesis; 3T3-L1 differentiation; PPAR${\gamma}$; SREPB-1c;
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