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Anti-inflammatory Effects of Sophora Japonica Aqueous Extract  

Bae, Gi-Sang (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Jo, Beom-Yeon (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Kim, Min-Sun (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Park, Kyoung-Chel (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Koo, Bon-Soon (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Seo, Sang-Wan (ChungBuk Oriental Medicine Center)
Kim, Sung-Gyu (ChungBuk Oriental Medicine Center)
Yun, Seung-Won (ChungBuk Oriental Medicine Center)
Jung, Won-Seok (Division of Constitutional Medicine Research, Korea Institute of Oriental Medicine)
Ham, Kyung-Wan (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Song, Ho-Joon (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Youn, Myung-Ja (Vestibulocochlear Research Center, College of Medicine, Wonkwang University)
Jeon, Ho-Seong (Professional Graduate School of Oriental Medicine, Wonkwang University)
Kwon, Kang-Beom (Department of Physiology, College of Oriental Medicine, Wonkwang University)
Kim, Jae-Hyo (Department of Meridian & Acupoint, College of Oriental Medicine, Wonkwang University)
Park, Sung-Joo (Department of Herbology, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.6, 2009 , pp. 1392-1398 More about this Journal
Abstract
The purpose of this study was to investigate the anti-inflammatory effects of aqueous extract from Sophora Japonica (SJ) on the RAW 264.7 cells. To evaluate the anti-inflammatory effects of SJ, we examined the cytokine productions including nitric oxide (NO), interleukin (IL)-1b, IL-6 and tumor necrosis factor-a (TNF-a) in lipopolysaccharide (LPS)-induced RAW 264.7 cells and also inhibitory mechanisms such as mitogen-activated protein kinases (MAPKs) and nuclear factor kappa b (NF-kB) using Western blot. SJ inhibited LPS-induced production of NO, TNF-a but not of IL-1b and IL-6 in RAW 264.7 cells. SJ inhibited the activation of MAPKs such as extracelluar signal-regulated kinase (ERK 1/2), c-Jun NH2-terminal kinase (JNK) and p38 but not of NF-kB in the LPS-stimulated RAW 264.7 cells. In conclusion, SJ down-regulated LPS-induced NO and TNF-a productions via MAPKs, which could be a clinical basis for inflammatory diseases and autoimmune diseases.
Keywords
Sophora Japonica (SJ); lipopolysaccharide (LPS); inflammation; cytokine;
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