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Anti-sclerotic Effect of Cinnamomi Ramulus Via Suppression of MMP-9 Activity and Migration of TNF-$\alpha$-induced HASMC  

Kim, Jai-Eun (Department of Pathology, College of Oriental Medicine, Dongguk University)
Lee, Chang-Sup (Department of Pathology, College of Oriental Medicine, Dongguk University)
Choi, Sung-Kyu (Department of Pathology, College of Oriental Medicine, Dongguk University)
Choi, Dall-Yeong (Department of Pathology, College of Oriental Medicine, Dongguk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.5, 2009 , pp. 974-979 More about this Journal
Abstract
Proliferation of vascular smooth muscle cell(VSMC) is one of the key features in onset of atherosclerosis and restenosis after vascular surgery such as stent implant. Atherosclerotic plaques are usually composed of collagen, elatsin and smooth muscle cells. Release of matrix metalloproteinases(MMPs) is considered to have correlation with development of atherosclerotic plaques. Based on the hypothesis that MMP inhibition would be helpful in the treatment of atherosclerosis, we investigated inhibition of MMP activity and migration of TNF-$\alpha$-induced human aortic smooth muscle cell(HASMC) by Cinnamomi Ramulus(CC). The result from gelatin zymography showed that CC inhibited MMP-9 activity in a dose-dependent manner. In addition, CC considerably inhibited the migration of HASMC induced by TNF-$\alpha$, while it showed little cytotoxic effect on HASMC. These results suggest that CC can be a potential anti-atherosclerotic agent through inhibition of MMP-9 activity and SMC migration.
Keywords
Cinnamomi Ramulus(CC); HASMC; atherosclerosis; TNF-$\alpha$; MMP-9; migration;
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Times Cited By KSCI : 2  (Citation Analysis)
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