Browse > Article

Effects of Yijin-tang-gamibang Extracts on Reflux Esophagitis  

Hwang, Gee-Young (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
Kim, Dae-Jun (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
Byun, Joon-Seok (3rd Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.5, 2009 , pp. 1073-1079 More about this Journal
Abstract
The object of this study was to observe the protective effects of Yijin-tang-gamibang (YJGMB), Yijin-tang has been traditionally used as Korean medicine for treating various digestive diseases. The study showed that it is effective on reflux esophagitis induced by pylorus and forestomach ligation in rats. Three different dosages of Yijin-tang-gamibang extracts, 300, 150 and 75 mg/kg, were once orally administered 1 hour before pylorus ligation. 6 groups, each of 8 rats per group were used in the present study. The results were compared with Omeprazole, antioxidant and proton pump inhibitor, 30 mg/kg treated group. Yijin-tang-gamibang extracts 300 mg/kg were showed similar or slightly lower effects as compared with 30 mg/kg of omeprazole in the present study. Detail mechanism studies should be conduced in future with the efficacy tests of individual herbal composition of Yijin-tang-gamibang and the screening of the biological active compounds in herbs.
Keywords
gastroesophageal reflux disease; Yijin-tang; omeprazole;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Farhadi, A., Fields, J., Banan, A., Keshavarzian, A. Reactive oxygen species: are they involved in the pathogenesis of GERD, Barrett's esophagus and the Latter's progression toward Esophageal cancer? Am J Gastroenterol. 97(1):22-26, 2002   DOI   ScienceOn
2 Claiborne, A. Catalase activity. In: Greenwald RA. (Ed.), CRS Handbook of Methods for Oxygen Radical Research. CRC Press:Boca Raton. pp 283-284, 1985
3 박인서, 함기백, 임대순. 유리산소기와 소화기계 질환. 진단과 치료. 13(5):548-554, 1993
4 DeVault, K.R., Castell, D.O. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol. 94(6):1434-1442, 1999   DOI   ScienceOn
5 Barron, J.J., Tan, H., Spalding, J., Bakst, A.W., Singer, J. Proton pump inhibitor utilization patterns in infants. J Pediatr Gastroenterol Nutr. 45(4):421-427, 2007   DOI   ScienceOn
6 McKeage, K., Blick, S.K., Croxtall, J.D., Lyseng Williamson, K.A., Keating, G.M. Esomeprazole: a review of its use in the management of gastric acid-related diseases in adults. Drugs. 68(11):1571-1607, 2008   DOI   ScienceOn
7 오중한, 김봉석, 임희용, 김동우, 최빈혜, 허진일, 조종관, 김대준, 변준석. 이진탕가미방 투여후 호전된 기능성 소화불량 환자 3례에 대한 증례보고. 대한한방내과학회지 26(3):641- 651, 2005   과학기술학회마을
8 Gartner, L.P., Hiatt, J.L. Color Textbook of Histology, third edition, Elsevier:Philadelphia. pp 381-411, 2007
9 Das, D., Banerjee, R.F. Effect of stress on the antioxidant enzymes and gastric ulceration. Mol Cell Biochem. 125(2):115-125, 1993   DOI   ScienceOn
10 정우, 이창현, 고병문, 이광규. 二陳湯 전탕액이 흰쥐 위의 Gastrin, Histamine, Somatostatin 면역반응세포에 미치는 영향. 동의병리학회지 15(4):554-559, 2001   과학기술학회마을
11 Rao, C.V., Vijayakumar, M. Effect of quercetin, flavonoids and alpha-tocopherol, an antioxidant vitamin on experimental reflux oesophagitis in rats. Eur J Pharmacol. 589(1/3):233-238, 2008   DOI   ScienceOn
12 Sharma, J.N., Al, Omran, A., Parvathy, S.S. Role of nitric oxide in inflammatory diseases. Inflammopharmacology. 15(6):252-259, 2007   DOI   ScienceOn
13 김봉석, 임희용, 오중한, 김동우, 최빈혜, 허진일, 김대준, 변준석. 이진탕가미방과 침치료를 병행한 비미란성 위식도역류질환 환자 7인 증례보고. 대한한방내과학회지 26(4):926- 934, 2005   과학기술학회마을
14 Department of Health, Education, and Welfare Publication (National Institute of Health) pp 85-23, 1985
15 Hunt, R.H. Importance of pH control in the management of GERD. Arch Intern Med. 159(7):649-657, 1999   DOI   PUBMED   ScienceOn
16 DeMeester, T.R., Wernly, J.A., Bryant, G.H., Little, A.G., Skinner, D.B. Clinical and in vitro analysis of determinants of gastroesophageal competence: a study of the principles of antireflux surgery. Am J Surg. 137(1):39-46, 1979   DOI   ScienceOn
17 鞠潤範, 金相贊, 朴宣東, 朴性奎, 徐富一, 徐榮培, 申舜植, 李尙仁, 李長泉, 李凞熙, 鄭宗佶, 朱榮丞, 崔湖榮. 方劑學. 서울, 圖書出版 永林社, p 528
18 Nakamura, K., Ogawa, Y., Furuta, Y., Miyazaki, H. Effects of sodium polyacrylate (PANa) on acute esophagitis by gastric juice in rats. Jpn J Pharmacol. 32: 445-456, 1982   DOI   PUBMED
19 Bicakci, U., Tander, B., Ariturk, E., Aydin, B.K., Aydin, O., Eren, R.R.Z., Bernay, F. Effects of omeprazole and gentamicin on the biochemical and histopathological alterations of the hypoxia/reoxygenation induced intestinal injury in newborn rats. Pediatr Surg Int. 21(10):800-805, 2005   DOI   ScienceOn
20 Katz, P.O. Lessons learned from intragastric pH monitoring. J Clin Gastroenterol. 33(2):107-113, 2001   DOI   PUBMED   ScienceOn
21 장태수. 이진탕의 진통 진경(鎭痙) 소염 및 GASTRIN 과 UROPEPSIN 의 분비에 미치는 영향. 東西醫學, 7(1):46-48, 1982
22 Min, Y.S., Bai, K.L., Yim, S.H., Lee, Y.J., Song, H.J., Kim, J.H., Ham, I., Whang, W.K., Sohn, U.D. The effect of luteolin-7-O-beta-D-glucuronopyranoside on gastritis and esophagitis in rats. Arch Pharm Res. 29(6):484-489, 2006   DOI   ScienceOn
23 Wiseman, H., Halliwell, B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progressive to cancer. Biochem J. 313(1):17-29, 1996   DOI
24 Meuwissen, S.G.M., Klinkenberg, Knol, E.C. Treatment of reflux oesophagitis with H2-receptor antagonist. Scand J Gastroenterol. 23 Suppl 146: 201-213, 1988
25 김행애. 二陳湯이 白鼠 胃運動 및 胃液分泌에 미치는 影響. 圓光大學校 大學院 석사학위논문. pp 1-29, 1990
26 Spechler, S,J. Comparison of medical and surgical therapy for complicated gastroesophageal reflux disease in Veteran. N Eng J Med. 326(12):786-792, 1992   DOI   ScienceOn
27 Tonini, M., Vigneri, S., Neri, M., Cuomo, R., Savarino, V., Pace, F. Potential options to optimize therapy of gastroesophageal reflux disease with proton pump inhibitors. Digestion. 76(3/4):171-178, 2007   DOI   ScienceOn
28 허준. 동의보감. 서울. 법인문화사. pp 1126-1166, 1210-1214, 2002
29 김동현, 김형민, 류종훈, 엄재영, 김상찬, 양재하, 조민경, 임종필, 홍승헌. 한방약리학, 서울, 신일상사, pp 49-53, 115-121. 243-246, 279-282, 561-562, 586, 613-619, 2006
30 Katada, K., Yoshida, N., Isozaki, Y., Tomatsuri, N., Ichikawa, H., Naito, Y., Okanoue, T., Yoshikawa, T. Prevention by rebamipide of acute reflux esophagitis in rats. Dig Dis Sci. 50(1):S97-103, 2005   DOI