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Anti-mechanical Hyperalgesic Effect of Lonicera Japonica in Neuropathic Pain Rats  

Hwang, Hye-Jeong (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University)
Kim, Hee-Young (Department of Neuroscience and Cell Biology, University of Texas Medical Branch)
Lee, Hye-Jung (Department of Meridian and Acupuncture, College of Oriental Medicine, Kyung-Hee University)
Lee, Bae-Hwan (Medical Research Center and Brain Research Institute, Yonsei University College of Medicine)
Shim, In-Sop (Department of Integrated Medicine, College of Medicine, The Catholic University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.4, 2009 , pp. 895-897 More about this Journal
Abstract
Lonicera japonica has been widely used for chronic inflammatory diseases in many Asian countries. Its analgesic effect has not been explored yet. This study aimed to test the analgesic potential of methanol extracts from Lonicera japonica (MELJ) in rat neuropathic mctel. Neuropathic pain was pacts ed by partial sciatic nerve injury. Two weeks after surgery, neuropathic rats received oral administration of MELJ at doses of either 0.0 g/kg, 0.2 g/kg or 0.4 g/kg. At dose of 0.0 g, rats were administered with saline only and used as conracl. The behavioral tests for f 0.0 g, raand ccld hs were adma were weformed up to 2 hours after treatment. The MELJ at the dose 0.4 g/kg dmg gfg, ntly alleviated f 0.0 g, rahyperalgesia, but not cold hyperalgesia. These results showed that the MELJ had, although transient, analgesic effect on mechanical hyperalgesia in the rat neuropathic model.
Keywords
Ionicera japonica; neuropathic pain; mechanical hyperalgesia;
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