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Anti-obesity Effect of Mulberry Leaves Extraction in Obese Rats High-fat Diet  

Kim, Eun-Jung (Department of Physical Therapy, Dongshin University)
Kim, Gye-Yeop (Department of Physical Therapy, Dongshin University)
Kim, Young-Min (Donguinara Co.)
Choi, Kung-Ho (Jeonnam Technopark)
Jang, Seong-Joo (Department of Radiology, Dongshin University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.4, 2009 , pp. 831-836 More about this Journal
Abstract
The aims of this investigation was to examine the anti-obesity effects of oral administration with Mulberry leaves extraction in the high-fat diet induced obesity rats. We investigated the anti-obesity effects of the extract from Mulberry leaves on the progress of high fat diet for 8 weeks. Experimental rats were divided into 5 different experimental groups including an normal group (normal dieat; n=10), control group (high fat diet; n=10), I (Mulberry leaves extraction 100 mg/kg oral administration induced obesity; n=10), II (Mulberry leaves extraction 300 mg/kg oral administration; n=10), and III (Mulberry leaves extraction 500 mg/kg oral administration; n=10). It is to analysis changes in body weight, epididymal fat weight, blood lipid profiles, and fat histological findings. Body weights were significantly increase in control group than normal groups(p<0.05). The level of total cholesterol, LDL-C and TG were significantly lower in experimental groups than control group (p<0.05). In histopathologic finding of fat-tissue around testicle experimental group I and II were more decreased than high fat diet-induced control group in fat cell size. These results suggested that the Mulberry leaves extraction oral administration made the increase of anti-obesity effect in high-fat diet induced obesity rats.
Keywords
mulberry leaves; obesity; rats;
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