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Inhibitory Effect of Galgeunhaegi-Tang on Compound48/80 Stimulated Allergic Reaction  

Kim, Hyung-Kap (Department Pathology, College of Oriental Medicine, Deagu Haany University)
Shin, Sang-Woo (Pusan National University)
Park, Jong-Hyun (Department Pathology, College of Oriental Medicine, Deagu Haany University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.2, 2009 , pp. 381-388 More about this Journal
Abstract
The present study was conducted to investigate the anti-allergic activity of Galgeunhaegi-Tang(GHT). We investigated the anti-allergic effects of GHT in RBL-2H3 basophilic leukemia cells by compound48/80, a mast cell degranulator and compound 48/80 induced anaphylactic shock in mice. GHT significantly inhibited ${\beta}$-hexosaminidase and histamine release from compound 48/80 stimulated RBL-2H3 cells. In addition, GHT effectively inhibited anaphylactic shock in mice by 40% at a dose 100 mg/mouse versus PBS treated control after the l.p injection(8 mg/kg) of compound 48/80. The in vitro anti-inflammatory activities of GHT in LPS-stimulated RAW 264.7 cells were investigated. GHT inhibited NO production in LPS-stimulated RAW 264.7 cells and effectively dowregulated the expression of iNOS mRNA and iNOS protein expression in LPS-stimulated RAW 264.7 cells. These result provide evidences that GHT may be beneficial in the treatment of allergic inflammtory disease.
Keywords
Galgeunhaegi-Tang; compound 48/80; ${\beta}$-hexosaminidase; histamine release; nitric oxide;
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Times Cited By KSCI : 3  (Citation Analysis)
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