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Screening of Antioxidative, Anti-thrombotic and Anti-atherosclerotic Effects of Moutan Root Bark Extracts  

Ban, Chang-Kye (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University)
Lee, Min-Ja (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University)
Lee, Hye-Sook (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University)
Jung, Hyun-Jung (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University)
Kim, Hyuck (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University)
Kim, Jai-Eun (Cardiovascular Medical Research Center and Department of Pathology, College of Oriental Medicine, Dongguk University)
Park, Sun-Dong (Cardiovascular Medical Research Center and Department of Prescriptionology, College of Oriental Medicine, Dongguk University)
Park, Won-Hwan (Cardiovascular Medical Research Center and Department of Diagnostics, College of Oriental Medicine, Dongguk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.1, 2009 , pp. 135-143 More about this Journal
Abstract
There is currently increased interest in the identification of antioxidant compounds that are pharmacologically potent and have low or no side effects. Plants produce significant amounts of antioxidants to prevent the oxidative stress caused by photons and oxygen, therefore they represent a potential source of new compounds with antioxidant activity. Moutan Root Sark (MRS) has been frequently used as analgesic. antispasmodic, anti-inflammatory and remedies for female diseases. In this study. the antioxidant activity of extract from MRS was studied in vitro methods by measuring the antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on $Cu^{2+}$ induced human LDL oxidation and the inhibitory effect on collagen induced platelet aggregation. The MRS extracts were found to have a potent scavenging activity, as well as an inhibitory effect on LDL oxidation and on platelet aggregation. In conclusion, the MRS extracts have anti-oxidative and anti-atherosclerotic effects in vitro system, which can be used for developing pharmaceutical drug against oxidative stress and atherosclerosis.
Keywords
Moutan Root Sark(MRS); antioxidative; anti-atherosclerotic; anti-hypertensive;
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Times Cited By KSCI : 2  (Citation Analysis)
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