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Effect of the Ethanol Extract from Lavandula vera on ${\alpha}$-MSH Induced Melanogenesis  

Kim, Ho-Min (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Jang, Yeong-Mi (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Han, Kyu-Soo (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Moon, Dea-Won (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
Mun, Yeun-Ja (Department of Anatomy, College of Oriental Medicine, Wonkwang University)
Woo, Won-Hong (Research Center of Traditional Korean Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.22, no.6, 2008 , pp. 1444-1448 More about this Journal
Abstract
Down-regulation of melanin synthesis is required for recovery of pigmentary disorders and it is well known that ${\alpha}$-MSH induced melanin synthesis and dendrite outgrowth on melanocytes. This study was conducted to evaluate the depigmenting properties of ethanol extract from a Lavandula vera. The ethanol extract from Lavandula vera inhibited melanin contents and tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the ethanol extract of Lavandula vera effectively suppressed the ${\alpha}$-MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the ${\alpha}$-MSH-induced mRNA expression of tyrosinase was significantly attenuated by Lavandula vera treatment. These results suggest that Lavandula vera exerts its depigmenting effects through the suppression of tyrosinase and cytoplasmic dendricity. And it may be a potent depigmetation agent in hyperpigmentation condition.
Keywords
Lavandula vera; melanin; tyrosinase; ${\alpha}$-MSH;
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Times Cited By KSCI : 2  (Citation Analysis)
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