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Anti-inflammatory Effect of Anemarrhenae Rhizoma on Collagen Induced Arthritis - a Model for Rheumatoid Rrthritis in DBA/1J Mice and Cytokine Production in Raw264.7 Cells  

Jeong, Keun-Kie (Department of Oriental Pathology, College of Oriental Medicine & Institute of Oriental Medicine, Kyunghee University)
Kang, Hee (Brain Korea 21 Oriental Medical Science Center)
Myung, Eu-Gene (Department of Oriental Pathology, College of Oriental Medicine & Institute of Oriental Medicine, Kyunghee University)
Shim, Bum-Sang (Department of Oriental Pathology, College of Oriental Medicine & Institute of Oriental Medicine, Kyunghee University)
Kim, Sung-Hoon (Cancer Preventive Material Development Research Center)
Choi, Seung-Hoon (Department of Oriental Pathology, College of Oriental Medicine & Institute of Oriental Medicine, Kyunghee University)
Ahn, Kyoo-Seok (Department of Oriental Pathology, College of Oriental Medicine & Institute of Oriental Medicine, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.22, no.6, 2008 , pp. 1416-1422 More about this Journal
Abstract
In order to examine anti-inflammatory effect of Anemarrhenae Rhizoma (AR) alcohol extract on rheumatoid arthritis, the present study investigated the viability and TNF-${\alpha}$ production in Raw264.7 cells treated with AR and collagen induced arthritis in DBA/1J mice which were orally administered with AR prior to immunization. The results are as follows: AR extract at 20 and 50${\mu}g$/ml inhibited the viability of Raw264.7 by 35% and 79%, respectively. AR showed a significant decrease in TNF-${\alpha}$ levels from Raw264.7 cells treated with LPS. AR administration significantly decreased arthritic index in DBA/1J mice immunized with bovine collagen type II. AR administration significantly decreased spleen weights obtained from mice in 6 weeks after immunization. AR administration significantly decreased serum anti-type II collagen antibody levels compared with control group. AR administration decreased serum IL-6 levels compared with control group but it did not reach statistical significance.
Keywords
Anemarrhenae Rhizoma; collagen; rheumatoid arthritis; TNF-${\alpha}$;
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