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Study on The Responseness to Oriental Medicine Therapy and Single-Nucleotide Polymorphism in Korean Cerebral Infarction Patients  

Lee, Se-Yun (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Haany University)
Lee, Yoon-Kyoung (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Haany University)
Kim, Jae-Su (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Haany University)
Lee, Kyung-Min (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Haany University)
Jung, Tae-Young (JeHan Oriental Medical Academy)
Lim, Seong-Chul (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Daegu Haany University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.22, no.4, 2008 , pp. 993-999 More about this Journal
Abstract
Ischemic brain injury such as cerebral infarction is characterized by acute local inflammatory response mediated by cytokines. The mechanism of cytokines involved in cerebral infarction progression are uncompletely revealed yet. We investigated to find out the relationship between single nucleotide polymorphism (SNP) of interleukin 4 receptor(IL4R) and Oriental Medicine therapy efficacy in patients with cerebral infarction for 2 weeks. Oriental Korean Medicine therapies (herbal medicine and acupuncture) were applied daily and motor functions of patients were assessed using the modified cerebral vascular accident (MCVA) scores. Genotyping for IL4R polymorphism was done by pyrosequencing analysis. In IL4R genotypes and the frequency of alleles, there was no significant difference between cerebral infarction patients (n=124) and controls group (n=175). And there was also no significant difference among good and bad responders in cerebral infarction patients. In this study the IL4R genotype might not be the risk factor or a good predictive genetic marker for good and bad responders in cerebral infarction patients in Korean. Further studies including different cytokine genes will be necessary for the exact genetic markers.
Keywords
Interleukin 4 Receptor (IL4R); gene; polymorphism; cerebral infarction; modified cerebral vascular accident (MCVA) scores; Oriental Medicine therapy;
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