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Inhibitory Effect of Oyster Conchioloin on Pro-inflammatory Mediator in Lipopolysaccharide;Activated Raw 264.7 Cells  

Park, Sang-Mi (College of Oriental Medicine, BK21 Team, Daegu Haany Univeity)
Zhao, Rong Jie (Mudanjiang Medical University)
Lee, Jong-Rok (College of Oriental Medicine, Daegu Haany Univeity)
Lee, Chul-Won (Seojin Biotech Co., Ltd)
Kim, Hak-Ju (Seojin Biotech Co., Ltd)
Kwon, Young-Kyu (College of Oriental Medicine, BK21 Team, Daegu Haany Univeity)
Kim, Sang-Chan (College of Oriental Medicine, BK21 Team, Daegu Haany Univeity)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.22, no.4, 2008 , pp. 878-883 More about this Journal
Abstract
Conchiolin is a complex protein which is secreted by the mollusc's outer epithelium to be the organic basis of mollusc shell. This study is to investigate a potential anti-inflammatory activity of conchiolin of oyster shell (COS). We tested the effects of COS on the lipopolysaccharide (LPS)-induced production of nitric oxide (NO) and prostaglandin E2 (PGE 2) in a murine macrophage cell line, RAW 264.7. COS inhibited production of NO and PGE2 in a dose dependent manner and also decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) and interleukin-6 (IL-6). These results suggest that COS can inhibit production of pro-inflammatory mediators and might be a useful source to treat inflammation.
Keywords
Conchiolin; Shell of oyster; iNOS; COX-2;
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