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Anti-inflammatory Effect of Cinnamomi Ramulus on Collagen Induced Arthritis;a Model for Rheumatoid Arthritis in DBA/1J Mice and Cytokine Production in Raw264.7 Cells  

Kim, Sung-Joon (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University Institute of Oriental Medicine, Kyunghee University)
Park, Sung-Min (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University Institute of Oriental Medicine, Kyunghee University)
Kang, Hee (Brain Korea 21 Oriental Medical Science Center)
Shim, Bum-Sang (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University Institute of Oriental Medicine, Kyunghee University)
Kim, Sung-Hoon (Cancer Preventive Material Development Research Center)
Choi, Seung-Hoon (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University Institute of Oriental Medicine, Kyunghee University)
Ahn, Kyoo-Seok (Department of Oriental Pathology, College of Oriental Medicine, Kyunghee University Institute of Oriental Medicine, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.22, no.3, 2008 , pp. 542-547 More about this Journal
Abstract
In order to examine anti-inflammatory effect of Cinnamomi Ramulus (CR) alcohol extract on rheumatoid arthritis, the present study investigated the viability and TNF-${\alpha}$ production in Raw264.7 cells treated with CR and collagen induced arthritis in DBA/1J mice which were orally administered with CR prior to immunization. The results are as follows: CR extract at $20{\mu}g/ml$ inhibited the viability of Raw264.7 by 50%. CR at 15 and $20{\mu}g/ml$ showed a significant decrease in TNF-${\alpha}$ levels from Raw264.7 cells treated with LPS. CR administration decreased arthritic index in DBA/1J mice immunized with bovine collagen type II but it did not reach statistical significance. CR administration significantly decreased spleen weights obtained from mice in 6 weeks after immunization. CR administration significantly decreased serum anti-type II collagen antibody levels compared with control group. CR administration decreased serum IL-6 levels compared with control group but it did not reach statistical significance.
Keywords
Cinnamomi Ramulus (CR); collagen; rheumatoid arthritis; TNF-${\alpha}$;
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1 Lipsky, P.E., van der Heijde, D.M.F.M., Clair, E.W.S., Furst, D.E., Breedveld, F.C., Kalden, J.R., Smolen, J.S., Weisman, M., Emery, P., Feldmann, M., Harriman, G.R., Maini, R.N. N. Eng. J. Med. 343: 1594-1602, 2000   DOI   ScienceOn
2 서영배. 동충하초가 synovial 세포 증식과 collagen에 의해 유발된 생쥐의 관절염 억제에 미치는 영향. 경희대학교 박사학위논문, 2000
3 Feldman, M., Maini, R.N., Bondeson, J., Taylor, P., Foxwell, B.M., Brennan, F.M. Cytokine blockade in rheumatoid arthritis. Adv Exp Med Biol 490: 119-127, 2001
4 R., Holmdahl, R., Bockermann, Johan Backlund, H., Yamada. The molecular pathogenesis of collagen-induced arthritis in mice- a model for rheumatoid arthritis. Ageing Research Reviews 1: 135-147, 2002   DOI   ScienceOn
5 Seki, N., Sudo, Y., Yoshioka, T., Sugihara, S., Fujitsu, T., Sakuma, S., Ogawa, T., Hamaoka, T., Senoh, H., Fujiwara, H. Type II collagen induced murine arthritis. I. Induction and perpetuation of arthritis require synergy between humoral and cell-mediated immunity. J Immunol 140: 1477-1484, 1988
6 Myers, L.K., Seyer, J.M., Stuart, J.M., Terato, K., David, C.S., Kang, A.H. T cell epitopes of type II collagen that regulate murine collagen induced arthritis. J Immunol. 151: 500-505, 1993
7 Mauri, C., Williams, R.O., Walmsley, M., Feldmann, M. Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis. Eur J Immunol 26: 1511-1518, 1996   DOI   ScienceOn
8 Svensson, L., Jirholt, J., Holmdahl, R., Jansson, L. B cell-deficient mice do not develop type II collagen-induced arthritis. Clin Exp Immunol 148: 2103-2108, 1992
9 이호근. 대강활탕이 제II형 Collagen 유발 관절염의 항체에 미치는 영향. 한방재활의학과학회지 4(1):87-99, 1994
10 Mindrescu, C., Thorbecke, G.J., Klein, M.J., Vilcek, J., Wisniewski, H.G. Amelioration of collagen-induced arthritis in DBA/1J mice by recombinant TSG-6, a tumor necrosis factor/interleukin- 1-inducible protein. Arthritis Rheum 43: 2668-2677, 2000   DOI   ScienceOn
11 Y., Ono, M., Inoue, H., Mizukami, Y., Ogihara. Suppressive Effect of Kanzo-bushi-to, a Kampo Medicine, on Collagen- induced arthritis. Biol. Pharm. Bull. 27(9):1406-1413, 2004   DOI   ScienceOn
12 신병희. 계지작약지모탕이 제II형 Collagen 유발 관절염의 항체에 미치는 영향. 한방재활의학과학회지 4(1):121-133, 1994
13 박히준, 이지숙, 이재동, 김남재, 표지희, 강전모, 최일환, 김수영, 심범상, 이제현, 임사비나. 계지의 항염 효과에 관한 연구. 대한한의학회지 26(2):140-151, 2005
14 엄재원. 골담초가 제2형 collagen 유발 관절염의 항체에 미치는 영향. 한방재활의학과학회지 5(1):149-161, 1995
15 전국한의과대학공동교과편찬위원회. 본초학. 서울, 영림사, 156-157, 2004
16 Robbins, S.L., Kumar, V., Cotrans, R.S. Pathologic basis of disease. Philadelphia, W.B. Saunders Co. pp 51-92, 1994
17 Terato, K., Hasty, K.A., Reife, R.A., Cremer, M.A., Kang, A.H., Stuart, J.M. Induction of arthritis with monoclonal antibodies to collagen. J Immunol. 148: 2103-2108, 1992
18 유경주, 신현대, 정석희, 이종수, 김성수. 백호탕과 백호가계지탕이 류마토이드 관절염 및 human monocyte의 IL-8에 미치는 영향. 한방재활의학과학회지 5(1):79-92, 1995
19 신병희, 이종수, 신현대. 계지작약지모탕이 제II형 콜라젠 유발 관절염의 항체에 미치는 영향. 한방재활의학과학회지 4(1):121-133, 1994
20 Trentham, D.E., Townes, A.S., Kang, A.H. Autoimmunity to type II collagen: an experimental model of arthritis. J. Exp. Med. 146: 857-868, 1977   DOI   ScienceOn
21 Feldman, M. Development of anti-TNF therapy for rheumatoid arthritis. Nat Rev Immunol 2: 364-371, 2002   DOI   ScienceOn