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Immune-modulator Effect of Zanthoxyli Pericarpium Watet Extract  

Shin, Hye-Young (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Department of Oriental Medicine, Wonkwang University)
Chang, In-Ae (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Department of Oriental Medicine, Wonkwang University)
Zhang, Wen-Ji (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Department of Oriental Medicine, Wonkwang University)
Kim, Youn-Chul (College of Pharmacy, Wonkwang University School of Medicine)
Yun, Yong-Gab (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine, Department of Oriental Medicine, Wonkwang University)
Park, Hyun (Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.22, no.2, 2008 , pp. 410-414 More about this Journal
Abstract
In the recently, increased concern has been focused on the pharmacology and clinical utility of herbal extracts and derivatives as a drug or adjunct to chemotherapy and immunotherapy. Here we investigated the modulatory effects of the extract of Zanthoxyli Pericarpium (ZP) in production of inflammatory mediators from Raw264.7 cells and expression of CD86, CD14, toll-like receptor (TLR)-4 from peritoneal macrophage. ZP enhanced the production of NO and $TNF-{\alpha}$ as well as mRNA expression of iNOS and $TNF-{\alpha}$. Treatment of peritoneal macrophage with ZP resulted in the enhanced cell-surface molecules expression of CD86, CD14 and TLR4. We assayed the effect of ZP in cell proliferation and production of $IFN-{\gamma},\;TNF-{\alpha}$. ZP increased Con A-induced cell proliferation and production of $IFN-{\gamma},\;TNF-{\alpha}$. These studies indicate that ZP induces macrophage activation and suggest the possible use of ZP in macrophage-based immunotherapies
Keywords
Zanthoxyli Pericarpium$TNF-{\alpha}$; Nitric oxide; TLR4;
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