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Fermentation Increases Antidiabetic Effects of Acanthopanax Senticosusbhpark@chonbuk.ac.kr  

Ham, Seong-Ho (Han Seo Pharm. Co. Ltd.)
Lim, Byung-Lak (H&BT Co, Ltd.)
Yu, Jia-hua (Department of Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University)
Ka, Sun-O (Department of Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University)
Park, Byung-Hyun (Department of Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.22, no.2, 2008 , pp. 340-345 More about this Journal
Abstract
Extract of Acanthopanax senticosus has recently been demonstrated to possess significant antidiabetic potential, in accordance with the traditional use of this plant as an antidiabetic natural health product. The present study evaluated the effects of fermented extract (FE) of this plant on glucose-stimulated insulin secretion, glucose uptake, and streptozotocin-induced type 1 diabetes model. A 3 h pretreatment with FE prevented $IL-1{\beta}$ and $IFN-{\gamma}$ toxicity in isolated rat islets. However, it did not affect insulin-stimulated glucose uptake in C2C12 myotubes. In addition, pretreatment of mice with FE blocked the destruction of streptozotocin-induced islets and the development of type 1 diabetes. FE reduced blood glucose level, increased insulin secretion, and improved glucose tolerance in streptozotocin-treated mice, whereas nonfermented extract (NFE) had moderate effects. Immunohistochemical staining for insulin clearly showed that pretreatment with FE blocked the STZ-induced islets destruction and restored the number of islet cells that secreted insulin to the level of the control. Although the active principles and their mechanisms of action remain to be identified, FE may nevertheless represent a novel complementary therapy and a source of novel therapeutic agents against type 1 diabetes mellitus.
Keywords
Acanthopanax senticosus; fermentation${\beta}$ cells; cytokine; streptozotocin;
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1 Hasegawa, H. Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid. J Pharmacol Sci 95: 153-157, 2004   DOI   ScienceOn
2 Akao, T., Kobashi, K., Aburada, M. Enzymic studies on the animal and intestinal bacterial metabolism of geniposide. Biol Pharm Bull 17: 1573-1576, 1994   DOI   ScienceOn
3 Akao, T., Kobashi, K. Glycyrrhizin ${\beta}$-D-glucuronidase of Eubacterium sp. from human intestinal flora. Chem Pharm Bull (Tokyo) 35: 705-710, 1987   DOI   ScienceOn
4 Glatthaar-Saalmuller, B., Sacher, F., Esperester, A. Antiviral activity of an extract derived from roots of Eleutherococcus senticosus. Antiviral Res 50: 223-228, 2001   DOI   ScienceOn
5 Park, S.Y., Chang, S.Y., Yook, C.S., Nohara, T. New 3,4-seco-lupane-type triterpene glycosides from Acanthopanax senticosus forma inermis. J Nat Prod 63: 1630-1633, 2000   DOI   ScienceOn
6 Kobashi, Y., Nakajima, M., Niki, Y., Matsushima, T. A case of acute eosinophilic pneumonia due to Sho-saiko-to. Nihon Kyobu Shikkan Gakkai Zasshi 35: 1372-1377, 1997
7 Hasegawa, H., Sung, J.H., Benno, Y. Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. Planta Med 63: 436-440, 1997   DOI   ScienceOn
8 Vuong, T., Martineau, L.C., Ramassamy, C., Matar, C., Haddad, P.S. Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. Can J Physiol Pharmacol 85: 956-965, 2007   DOI   ScienceOn
9 Sui, D.Y., Lu, Z.Z., Li, S.H., Cai, Y. Hypoglycemic effect of saponin isolated from leaves of Acanthopanax senticosus (Rupr. et Maxin.) Harms. Zhongguo Zhong Yao Za Zhi 19: 683-685, 703, 1994
10 Yang, J.Y., Lee, K.S., Kim, M.K., Moon, S.K., Kang, M.K., Park, B.H., Kim, J.S., Park, J.W. Effect of Acanthopanax senticosus on lipoprotein lipase in 3T3-L1 adipocytes. Phytother Res 18: 160-163, 2004   DOI   ScienceOn
11 Xi, M., Hai, C., Tang, H., Chen, M., Fang, K., Liang, X. Antioxidant and antiglycation properties of total saponins extracted from traditional Chinese medicine used to treat diabetes mellitus. Phytother Res, 2007
12 De Vos, P., Lefebvre, A.M., Miller, S.G., Guerre-Millo, M., Wong, K., Saladin, R., Hamann, L.G., Staels, B., Briggs, M.R., Auwerx, J. Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma. J Clin Invest 98: 1004-1009, 1996   DOI   ScienceOn
13 Yim, J.S., Kim, Y.S., Moon, S.K., Cho, K.H., Bae, H.S., Kim, J.J., Park, E.K., Kim, D.H. Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Biol Pharm Bull 27: 1580-1583, 2004   DOI   ScienceOn
14 Yoshizumi, K., Hirano, K., Ando, H., Hirai, Y., Ida, Y., Tsuji, T., Tanaka, T., Satouchi, K., Terao, J. Lupane-type saponins from leaves of Acanthopanax sessiliflorus and their inhibitory activity on pancreatic lipase. J Agric Food Chem 54: 335-341, 2006   DOI   ScienceOn
15 Steinmann, G.G., Esperester, A., Joller, P. Immunophar- macological in vitro effects of Eleutherococcus senticosus extracts. Arzneimittelforschung 51: 76-83, 2001
16 Szolomicki, J., Samochowiec, L., Wojcicki, J., Drozdzik, M. The influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in man. Phytother Res 14: 30-35, 2000   DOI   ScienceOn
17 Kim, E.K., Kwon, K.B., Koo, B.S., Han, M.J., Song, M.Y., Song, E.K., Han, M.K., Park, J.W., Ryu, D.G., Park, B.H. Activation of peroxisome proliferator-activated receptor-${\gamma}$ protects pancreatic $\beta$-cells from cytokine-induced cytotoxicity via NF ${\kappa}B$ pathway. Int J Biochem Cell Biol 39: 1260-1275, 2007   DOI   ScienceOn
18 Liu, T.P., Lee, C.S., Liou, S.S., Liu, I.M., Cheng, J.T. Improvement of insulin resistance by Acanthopanax senticosus root in fructose-rich chow-fed rats. Clin Exp Pharmacol Physiol 32: 649-654, 2005   DOI   ScienceOn
19 Bae, E.A., Han, M.J., Kim, E.J., Kim, D.H. Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants. Arch Pharm Res 27: 61-67, 2004   DOI
20 Hooper, L.V., Wong, M.H., Thelin, A., Hansson, L., Falk, P.G., Gordon, J.I. Molecular analysis of commensal host-microbial relationships in the intestine. Science 291: 881-884, 2001   DOI   ScienceOn
21 Gaffney, B.T., Hugel, H.M., Rich, P.A. The effects of Eleutherococcus senticosus and Panax ginseng on steroidal hormone indices of stress and lymphocyte subset numbers in endurance athletes. Life Sci 70: 431-442, 2001   DOI   ScienceOn
22 Akao, T., Kawabata, K., Yanagisawa, E., Ishihara, K., Mizuhara, Y., Wakui, Y., Sakashita, Y., Kobashi, K. Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. J Pharm Pharmacol 52: 1563-1568, 2000   DOI   ScienceOn
23 Kobashi, Y., Matsushima, T. Clinical analysis of recent lower lung field tuberculosis. J Infect Chemother 9: 272-275, 2003   DOI   ScienceOn
24 Eckburg, P.B., Bik, E.M., Bernstein, C.N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S.R., Nelson, K.E., Relman, D.A. Diversity of the human intestinal microbial flora. Science 308: 1635-1638, 2005   DOI   ScienceOn
25 Hibasami, H., Fujikawa, T., Takeda, H., Nishibe, S., Satoh, T., Fujisawa, T., Nakashima, K. Induction of apoptosis by Acanthopanax senticosus HARMS and its component, sesamin in human stomach cancer KATO III cells. Oncol Rep 7: 1213-1216, 2000
26 Hooper, L.V., Gordon, J.I. Commensal host-bacterial relationships in the gut. Science 292: 1115-1118, 2001   DOI   ScienceOn
27 Lin, C.C., Huang, P.C. Antioxidant and hepatoprotective effects of Acathopanax senticosus. Phytother Res 14: 489-494, 2000   DOI   ScienceOn