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Study on the Protective Effect of Corni Fructus Against Free Radical Mediated Liver Damage  

Ha, Ki-Tae (Department of Pathology, College of Oriental Medicine, Dongguk University)
Kim, Young-Mi (Department of Pathology, College of Oriental Medicine, Dongguk University)
Kim, Cheorl-Ho (Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University)
Choi, Dall-Yeong (Department of Pathology, College of Oriental Medicine, Dongguk University)
Kim, June-Ki (Department of Pathology, College of Oriental Medicine, Dongguk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.22, no.1, 2008 , pp. 82-88 More about this Journal
Abstract
We evaluated the potential protective activity of the traditional Korean medicinal herb, Corni fructus (CF), in an experimental model of hepatotoxicity induced by carbontetrachloride $(CCl_4)$. The CF exhibited a hepatoprotective activity against Chang cell. And The expression of cytochrome P450 2E1 (CYP2E1), measured by RT-PCR and western blot, was significantly decreased in the CF treated Chang cell. But $CCl_4$ and CF has no significant effect on 1A1 and 3A1 isoform of cytochrome P450. Based on these findings, it is suggested that hepatoprotective effects of CF possibly related to antioxidative effects and downregulation of CYP2E1 expression.
Keywords
Corni Fructus; cytochrome P450 2E1; carbon tetrachloride; hepatoprotection; antioxidative effect;
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