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Study on the Hepatoprotective Effect and Cytochrome P450 Regulation of Scutellaria Radix  

Ha, Ki-Tae (Department of Pathology, College of Oriental Medicine, Dongguk University)
Jeong, Sang-Shin (Department of Pathology, College of Oriental Medicine, Dongguk University)
Kim, Cheorl-Ho (Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University)
Choi, Dall-Yeong (Department of Pathology, College of Oriental Medicine, Dongguk University)
Kim, June-Ki (Department of Pathology, College of Oriental Medicine, Dongguk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.6, 2007 , pp. 1534-1542 More about this Journal
Abstract
In this study, the liver protective effect of the hot water extracts of Scutellaria radix (SR) was investigated. The SR exhibited a hepatoprotective activity against $CCl_4$-induced liver damage in Sprague-Dawley (SD) rats and Chang cell. And the SR also showed significant decrease of malodialdehyde (MDA) and increase of glutathion (GSH), catalase activity in rat liver homogenate. The expression of cytochrome P450 2E1 (CYP2E1), measured by RT-PCR and western blot, was significantly decreased in the SR treated SD rats and Chang cell. But $CCl_4$ and SR has no significant effect on 1A1 and 3A1 isoform of cytochrome P450. Based on these findings, it is suggested that hepatoprotective effects of SR possibly related to antioxidative effects and downregulation of CYP2E1 expression.
Keywords
Scutellaria radix; cytochrome P450 2E1; carbon tetrachloride; hepatoprotection; antioxidative effect;
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