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Effect of Houttuynia cordata Thunb and Herbs Mixture Extract on the Antioxidation in the LPS-induced Hepatotoxicity  

Kwon, Ryun-Hee (Department of Public Health, Graduate School of Public Health and Welfare)
Na, Bak-Ju (Department of Preventive Medicine, College of Medicine, Konyang University)
Park, Si-Jun (Professional Graduate School of Oriental Medicine, Wonkwang University)
Woo, Won-Hong (Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Moo-Sik (Department of Preventive Medicine, College of Medicine, Konyang University)
Mun, Yeun-Ja (Professional Graduate School of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.6, 2007 , pp. 1520-1524 More about this Journal
Abstract
The purpose of this study was to investigate the effects of Houttuynia cordata Thunb and Oriental Herb Mixture Extract (HCTM) through anti-oxidation against the hepatotoxicity-inducing lipopolysaccharide (LPS) in HCTM and LPS-treated rats. HCTM of 100 mg/kg concentration was intraperitoneally administered into rats at dose of 1.5 ml/kg for 20 days. On the day 21, 1.5 ml/kg of LPS was injected 5 hours before anesthetization. The activity of superoxide dismutase (SOD) was measured in mitochondrial fraction and malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPx) were measured in liver homogenate. LPS-treatment markedly increased the levels of MDA and significantly decreased those of SOD, CAT and GPx. But HCTM pretreatment significantly increased those of SOD, CAT and GPx by 86.9%, 57.2% and 72.7% respectively. Moreover HCTM pretreatment decreased the levels of MDA. These results showed the HCTM had the effects against the hepatotoxicity-inducing LPS in the anti-oxidation. This suggested that HCTM could be used for functional beverage.
Keywords
Houttuynia cordata; superoxide dismutase; malondialdehyde; catalase; glutathione peroxidase; antioxidation;
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