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Water Extracted Evodiae Fructus Possesses Immunomodulatory Activities on Cyclophosphamide Induced Immunesuppression  

Lee, Young-Sun (Department of Traditional Health Resource Development, College of Sung Duk)
Lee, Geum-Hong (Department of Pathology, College of Oriental Medicine, Deagu Haany University)
Park, Jong-Hyun (Department of Pathology, College of Oriental Medicine, Deagu Haany University)
Kwon, Young-Kyu (Department of Physiology, College of Oriental Medicine, Deagu Haany University)
Shin, Sang-Woo (School of Oriental Medicine, Pusan National University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.6, 2007 , pp. 1450-1455 More about this Journal
Abstract
Evodiae Fructus(EF) has been used as Traditional medicine for the treatment of headache, abdominal pain, hemorrhage, and menorrhae in many Asian countries. The present study was conducted to investigate the immunomodulatory effect on cyclophosphamide(CY)-induced immunesuppression of water extracted EF(EFE). In the mouse spleen cell proliferation assay, EFE enhanced mitogenic activity and restored the CY-induced cell suppression. In the nitric oxide(NO) assay, EFE inhibited NO production and iNOS protein levels in LPS-stimulated RAW 264.7 cells. In the GC-MS analysis, many ingredients of EFE were detected by solvents. These results indicated that EFE can modulate immune response through immune cell proliferation, the regulation of NO production and the inhibition of CY-induced immunotoxicity.
Keywords
Evodiae Fructus; immunomodulatory effect; cyclophosphamide; NO;
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1 김상태, 안승희, 김정도, 김영균. 오수유 MeOH 추출물이 Cyanide에 의한 신경세포의 보호효과에 미치는 영향. 생약학회지 34(4):282-287, 2003
2 Pellati, F., Benvenuti, S., Yoshizaki, F., Bertelli, D., Rossi, M.C. Headspace solid-phase microextraction-gas chromatography--mass spectrometry analysis of the volatile compounds of Evodia species fruits. J Chromatogr A 1087(1-2):265-273, 2005   DOI
3 Ueng, Y.F., Tsai, T.H., Don, M.J., Chen, R.M., Chen, T.L. Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats. J Pharm Pharmacol 57(2):227-232, 2005   DOI   ScienceOn
4 Lee, S.K., Kim, N.H., Lee, J., Kim, D.H., Lee, E.S., Choi, H.G., Chang, H.W., Jahng, Y., Jeong, T.C. Induction of cytochrome P450s by rutaecarpine and metabolism of rutaecarpine by cytochrome P450s. Planta Med 70(8):753-757, 2004   DOI   ScienceOn
5 표명윤, 현수미, 양기숙. 상황버섯 추출물이 정상 마우스와 cyclophosphamide로 처리된 마우스의 체액성 면역기능에 미치는 양향. 응용약물학회지 9: 194-200, 2001
6 Huang, D.M., Guh, J.H., Huang, Y.T., Chueh, S.C., Chiang, P.C., Teng, C.M. Induction of mitotic arrest and apoptosis in human prostate cancer pc-3 cells by evodiamine. J Urol 173(1):256-261, 2005   DOI   ScienceOn
7 중앙대사전. 서울, 성보사, p 1118, 1992
8 Artym, J., Zimecki, M., Kruzel, M. Normalization of peripheral blood cell composition by lactoferrin in cyclophosphamide-treated mice. Med Sci Monit 10(3):BR84-89, 2004
9 Zhang, Y., Wu, L.J., Tashiro, S., Onodera, S., Ikejima, T. Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis. Acta Pharmacol Sin 25(1):83-89, 2004
10 Kobayashi, Y. The nociceptive and anti-nociceptive effects of evodiamine from fruits of Evodia rutaecarpa in mice. Planta Med 69(5):425-428, 2003   DOI   ScienceOn
11 이영선, 권영규, 이금홍, 신상우. 건강 열수출액이 Methotrexate에 의해 유도된 마우스 면역억제 조절에 미치는 영향. 동의생리병리학회지 21(2):485-490, 2006   과학기술학회마을
12 Senthikumar, S., Devaki, T., Manohar, B.M., Babu, M.S. Effect of squalene on cyclophophamide-induced toxicity. Clin Chim Acta 364: 335-342, 2005   DOI   ScienceOn
13 Ueng, Y.F., Yu, H.J., Lee, C.H., Peng, C., Jan, W.C., Ho, L.K., Chen, C.F., Don, M.J. Identification of the microsomal oxidation metabolites of rutaecarpine, a main active alkaloid of the medicinal herb Evodia rutaecarpa. J Chromatogr A 1076(1-2):103-109, 2005   DOI
14 MacMicking, J., Xie, Q.W., nathan, C. Nitric oxide and macrophage function. Annu Rev immunol 15: 323-350, 1997   DOI   ScienceOn
15 전국한의과대학 본초학교수. 본초학. 서울, 영림사, pp 337-338, 1991
16 Artym, J., Zimecki, M., Paprocka, M., Kruzel, M.L. Orally administered lactoferrin restores humoral immune response in immunocompromised mice. Immunology Letters 89: 9-15, 2003   DOI   ScienceOn
17 Fei, X.F., Wang, B.X., Li, T.J., Tashiro, S., Minami, M., Xing de, J., Ikejima, T. Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells. Cancer Sci 94(1):92-98, 2003   DOI   ScienceOn
18 김성은, 김대근, 신태용, 임종필, 엄동욱. 흡광도 측정법에 의한 오수유탕 중 오수유 알칼로이드의 정량. 생약학회지 35(1):88-91, 2004
19 Tsai, T.H., Chang, C.H., Lin, L.C. Effects of Evodia rutaecarpa and rutaecarpine on the pharmacokinetics of caffeine in rats. Planta Med 71(7):640-645, 2005   DOI   ScienceOn
20 마진열, 하창수, 성현제, 지옥표. Cyclophosphamide로 Rat에 유도된 악성빈혈에 대한 숙지황의 증수에 따른 치료효능에 관한 연구. 생약학회지 32(3):325-334, 2005
21 왕본상. 현대중약약리학. 천진, 천진과학기술출판사, p 608, 1997
22 Wang, C., Wang, M.W., Tashiro, S., Onodera, S., Ikejima, T. Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death. J Pharmacol Sci 97(4):494-500, 2005   DOI   ScienceOn
23 Liao, C.H., Pan, S.L., Guh, J.H., Chang, Y.L., Pai, H.C., Lin, C.H., Teng, C.M. Antitumor mechanism of evodiamine, a constituent from Chinese herb Evodiae fructus, in human multiple-drug resistant breast cancer NCI/ADR-RES cells in vitro and in vivo. Carcinogenesis 26(5):968-975, 2005   DOI   ScienceOn
24 Lee, Y.S., Han, O.K., Park, C.W., Suh, S.I., Shin, S.W., Yang, C.H., Jeon, T.W., Lee, E.S., Kim, K.J., Kim, S.H., Yoo, W.K., Kim, H.J. Immunomodulatory effects of aqueous-extracted Astragali radix in methotrexate-treated mouse spleen cells. J. Ethno 84: 193-198, 2003   DOI
25 Alderton, W.K., Cooper, C.E., Knowles, R.G. Nitric oxide synthases: structure, function and inhibition. Biochem J 357(pt 3):593-615, 2001   DOI   ScienceOn
26 정보섭, 신민교. 향약대사전. 서울, 영림사, p 786, 1990
27 이성우, 황방연, 김세은, 김환묵, 김영호, 이경순, 이정준, 노재섭. 약용식물 오수유로부터 다제약제 내성 조절물질의 분리. 생약학회지 26(4):344-348, 1995
28 정수연, 박윤주, 정면우, 임화경, 강주희, 최기환, 김주일. 오수유가 선천성고혈압휜쥐의 혈압에 미치는 영향. 응용약물학회지 8(4):305-310, 2000
29 Zhang, Y., Wu, L.J., Tashiro, S., Onodera, S., Ikejima, T. Intracellular regulation of evodiamine-induced A375-S2 cell death. Biol Pharm Bull 26(11):1543-1547, 2003   DOI   ScienceOn
30 중초약학. 홍콩, 상무인서관, p 299, 1983