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Effect of Phellinus linteus on Differentiation and Cell Proliferation in Human Leukemia HL-60 cells  

Choi, Eun-Young (Graduate School of Education. Common-Science Education, Wonkwang University)
Ju, Seong-Min (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Park, Jin-Mo (Division of Natural Science, College of Natural Sciences, Wonkwang University)
Park, Jun-Ho (Division of Natural Science, College of Natural Sciences, Wonkwang University)
Han, Dong-Min (Division of Natural Science, College of Natural Sciences, Wonkwang University)
Jeon, Byung-Hun (Department of Pathology, College of Oriental Medicine, Wonkwang University)
Kim, Won-Sin (Division of Natural Science, College of Natural Sciences, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.5, 2007 , pp. 1170-1175 More about this Journal
Abstract
We have examined the effect of water extract of Phellinus linteus, a raw material of Korean traditional herbal medicine, on the induction of HL-60 cell differentiation. The proliferation of HL-60 cell was inhibited dose-dependently by treatment with various doses of P. linteus extract. It also caused a significant change in NBT reduction (7.5 times). The expression of CD11b and CD14 was increased in the cells treated with the extract, especially in those arrested at G0/G1 stage, which suggested that some components in P. Linteus extract induced HL-60 cell differentiation to granulocytic and monocyte lineages. Moreover, the expression levels of $p21^{WAF1/CIP}$ and $p27^{KIP}$ were up-regulated during HL-60 cell differentiation induced by P. Linteus extract. These results together suggest that P. Linteus extract contains potential HL-60 cell differentiation agents.
Keywords
HL-60; P. Linteus; differentiation; p27; p21; CD11b; CD14;
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