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Comparative Study on Antioxidative Effects of Mori Ramulus and Mori Cortex  

Cha, Yun-Yeop (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Sangji University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.4, 2007 , pp. 934-939 More about this Journal
Abstract
In recent year, We are concerned about anti-aging, disease-prevention, longevity, so many methods are used in solving this problem. And Those are related with antioxidative ability. Recently, We heard that Mori Cortex was known to reduce the hypertension and was helpful in promoting health, and Mori Ramulus was effective against obesity, etc. So, This study was performed to investigate the antioxidative effect of hot-water extracts of Mori Cortex and Mori Ramulus used for 3 methods, those are DPPH radical scavenging activity, Nitric oxide(NO) radical scavenging activity and Bovine serum albumin(BSA). And we compared Mori Cortex and Mori Ramulus on Antioxidative Effects. The results of this study were as follows: We measured levels of DPPH radical scavenging activity and Nitric oxide(NO) radical scavenging activity. And we obtained results that Mori Ramulus was most effective with the concentration of 5 $mg/m{\ell}$, and Mori Cortex was most effective with the concentration of 2.5 $mg/m{\ell}$, And we examined the antioxidative effects of Mori Ramulus and Mori Cortex with $CU^{2+}/H_20_2$-induced Bovine serum albumin(BSA). And we obtained that antioxidative ability was increased after 1.25 $mg/m{\ell}$ and that was most effective with the concentration of 5 $mg/m{\ell}$ on both of them. And antioxidative ability of Mori Cortex was better than Mori Ramulus(p<0.05). So I guess that hot-water extracts of Mori Ramulus and Mori Cortex have effects on antioxidative ability, but Mori Cortex is better than Mori Ramulus on antioxidation. Hereafter we need differential experimental methods of antioxidative effect on both of them.
Keywords
Mori Cortex; Mori Ramulus; antioxidative; DPPH radical scavenging activity; Nitric oxide(NO) radical scavenging activity; Bovine serum albumin(BSA);
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1 이상인 등. 한약임상응용. 서울, 성보사, p 187, 1986
2 Kai-Jin Wang, Ying-Jun Zhang, Chong-Ren Yang. Antioxidant phenolic constituents from Fagopyrum dibortrys. Journal of Ethnopharmacology 99: 259-264, 2005   DOI   ScienceOn
3 Manjeshwar Shrinath Baliga, Ganesh Chandra Janetia, Shaival Kamalakasha Rao and Kiran Babu S. Evaluation of nitric oxide scavenging activity of certain spices in vitro :A preliminary study. Nahrung/Food 47(4):261-264, 2003   DOI   ScienceOn
4 Park, Y.H. Effect of polyamine on modification of biommodics by aldehyde. PhD in Medicine Thesis. Seoul National University, 2000
5 Fang, Y.Z., Yang, S., Wu, G. Free radical, antioxidant and nutrition. Nutr. 18: 872-879, 2002   DOI   ScienceOn
6 Manach, C., Morand, C., Crespy, V., Demigne, C., Texier, O., Regerat, F., Remesy, C. Quercetin is recovered in human plasma as conjugated derivative which retain antioxidant properties. FEBS Lett. 426: 331-336, 1998   DOI   ScienceOn
7 Feher, J., Cosmos, G., Vereckei, A. The free radical theory of aging Free Radicals Reactions in Medicine. Springer-Verlag. Berlin. pp 57-59, 1987
8 南京中醫學院醫經敎硏組. 黃帝內經素問譯解. 上海, 上海科學技術出版社, pp 4-5, 1983
9 Monocada, S., Higgs, A. L-arginine nitric oxide pathway. NEng. J. Med. 329: 2002-2012, 1993   DOI   ScienceOn
10 박시원, 김경하. HTB 176 임파종 세포에 대한 상백피의 세포증식 억제효과. J. Basic Sci. 9: 105-115, 1996
11 張仲景. 金櫃要略. 대만, 동방서점, p 90, 1950
12 윤창용, 신동환, 홍충만, 이원규, 장동덕, 조재천, 안재규, 안덕균, 이무삼. 대식세포의 NO, TNF-$\alpha$ 및 IL-1 생산에 미치는 상백피의 억제 효과. 한국수의공중보건학회지 22(3):281-292, 1998
13 Rice-Evans, C.A., Miller, N.J., Paganga, G. Structure antioxidant activity relationships of flavonoids and phenolic acid. Free Radic Biol Med. 20: 933-956, 1996   DOI   ScienceOn
14 김영곤, 김영균. 프리radical. 서울, 여문각, pp 31-35, 98-101, 259-260, 278-286, 396-400, 425-426, 564-568, 1997
15 전국한의과대학 본초학교수 공편저. 본초학. 서울, 영림사, pp 274-275, 484-485, 1991
16 Kim, S.M., Cho, Y.S., Sung, S.K. The antioxidant ability and nitrite scavenging ability of plant extracts. Korean J Soc Food Sci Technol. 33: 626-632, 2001
17 곽영. 신길조, 조기호, 김영석, 배형섭, 이경섭. 상지, 상엽, 상백피 및 상심자의 항지혈 효과에 관한 연구. 경희의학 8(1):44-56, 1992
18 유경수, 안덕균. 상백피에 관한 연구(I). 생약학회지 11(2):85- 94, 1980
19 Cutler, R.G. Antioxidant, aging and longevity. Free Radicals in Biology(ed. Pryor, W.). Acedimic Press. 6: 371-424, 1984
20 홍원식 편. 精校黃帝內經. 서울, 東洋醫學硏究院, pp 19-20, 11, 246, 301, 1981
21 南京中醫學院醫經敎硏組. 黃帝內經素問譯解. 上海, 上海科學技術出版社, p 337, 1986
22 玉浴生. 中藥藥理與應用. 北京, 人民衛生出版社, pp 925-926, 1983
23 孫星衍編. 神農本草經 中品, 대만. 자유출판사, p 166, 1969
24 Masuda, T., Jitoe, A., Isobe, J., Nakatani, N., Yonemori, S. Anti-oxidative and anti-inflammatory curcumin-related phenolics from rhizomes of Curcuma domestica. Phytochemistry. 32: 1557-1560, 1993   DOI   ScienceOn
25 김숙희, 김화영. 노화. 서울, 민음사, pp 77-85, 94, 1991
26 장석태. 피부과학. 서울, 여문각, pp 23-25, 1994
27 Jung-Yi Bor, Hui-Yin Chen, Gow-chin Yen. Evalution of antioxidant and Inhibitory effects on Nitric Oxide Production of Some Common Vegetables. J. Agric. Doof Chem. 54: 1680-1686, 2006   DOI   ScienceOn
28 Dimmeler, S., Zeiher, A.M. Nitric oxide and apoptosis. Another paradigm for the double edged role of nitric oxide. Nitric oxide. 1(41):275-281, 1997   DOI   ScienceOn
29 E.R. Stadtman, Ann, N.Y. Acad. Sci. 928: 22-38, 2001   DOI
30 泗聯中心術生院編著. 中草藥製劑方法. 香港, 南務印書館, p 20, 1978
31 Blois, M.S. Antioxidant determination by the use of a stable free radical. Nature. 26: 1198-1120, 1958
32 那琦等編. 名醫別錄. 대만, 중국의약학원, p 78, 1977
33 蘇頌等. 新修本草. 대만, 국립중국의약연구소, p 362, 1971
34 Morrissey, P.A., O'Brien, N.M. Dietary antioxidant im health and disease. Int Dairy J. 8: 462-472, 1998
35 리정복. 장수학. 과학백과사전출판사, pp 11-99, 492-576, 1987
36 江蘇中醫學院編. 中藥大辭典. 中國, 上海科學技術出版社, pp 1479-1481, 1966, 1979
37 Youngman, L.D., Park, J.Y., Ames, B.N. Proc. Natl. Sci. U.S.A. 89: 9112-9116, 1992
38 Kim, Y.M., Bombeck, C.A. Nitric oxide as a bifunctional regulator of apoptosis. Circ. res. 1(4):253-256, 1999
39 강성용. 상백피가 피부암 및 골수암세포의 세포독성, NO 및 Apoptosis에 미치는 영향. 대한본초학회지 12(2), 1997
40 李獻平 外. 四大懷藥延綬衰老作用的硏究. 서울, 中西醫結合雜誌 11(8):486-487, 1991
41 Kim, H.Y. Statistical study of acne vulgaris in korean adolescence. Kor. J. Dermatol. 16: 471-476, 1978
42 Letteron, P., Labbbe, G., Degott, C., Berson, A., Fromenty, B., Delaforge, M., Larrey, D., Pessaycare, D. Mecanism for the proctective effects of silymarin against carbon tetra-chloride-induced lipid peroxidation and hepatotoxity in mice. Biochem Pharmacol. 39: 2027-2034, 1990   DOI   ScienceOn
43 Chung, H.T., Pae, H.O., Choi, B.M., Billiar, T.R., Kim, Y.M. Nitric oxide as a bioregulator of apoptosis. Biochem biophys rescommum. 282: 1075-1079, 2001   DOI   ScienceOn
44 Mayo, J.C., Tan, D.X., Sainz, R.M., Natarajan, M., Lopez- Burillo, S., Reiter. R.J. Protection against oxidative protein damage induced by metal-catalyzed reaction or alkylperoxyl radicals:comparative effects of melatonin and other antioxidants. Biochimica et Biophysica Acta. 1620: 139-150, 2003   DOI   ScienceOn