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Protective Effect of Licorice Water Extract against Cadmium-induced Nephro-toxicity in Rats  

Lee, Jong-Rok (College of Oriental Medicine, Daegu Haany University)
Kim, Sang-Chan (College of Oriental Medicine, Daegu Haany University. Development Team for The New Drug of Oriental Medicine(BK21 program), Daegu Haany University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.3, 2007 , pp. 771-775 More about this Journal
Abstract
Licorice has been used for cure of injuries and for detoxification in East Asia. This study investigated the protective effect of licorice water extract against cadmium (CdCl$_2$, Cd)-induced nephro-toxicity in rats. To induce acute toxicity, Cd (4 mg/kg body weight) was dissolved in normal saline and then, intravenously (i.v.) injected to animals. In experiments, animals were orally administrated with vehicle or licorice water extract (50-100 mg/kg) for 3 days, exposed to a single injection of Cd after 24 h the last licorice/vehicle treatment. Licorice protected kidney injuries by Cd treatment. The number of glomeruli showing vasodilatation and thickening of Bowman's capsule was dose-dependently decreased by licorice. These results suggest that licorice might be a potent preventive protector against Cd-induced nephro-toxicity in rats.
Keywords
licorice; cadmium; rat; kidney;
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