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Study on the Effect of Gwanjulbang-5 in Rheumatoid Arthritis  

Choi, Jae-Young (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Daejeon University)
Heo, Dong-Seok (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Daejeon University)
Yoon, Il-Ji (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Daejeon University)
Oh, Min-Seok (Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.3, 2007 , pp. 728-735 More about this Journal
Abstract
This study was carried out to know the effect of Gwanjulbang-5(hereinafter refer to GJB-5) to on Rheumatoid Arthritis by using human fibroblast-like synoviocytes(hFLS). We performed several experimetal items : that is cytotoxicity of GJB-5, mRNA expression of pro-imflammatory cytokines in hFLS and production of NO, ROS. The results were obtained as follows : GJB-5 reduced the production of pro-inflammatory cytokines TNF-${\alpha}$, IL-1${\beta}$, IL-6, IL-8 in hFLS, increased the production of TIMP-1. As well as GJB-5 reduced the production of ICAM-1, MMP-3, NOS-II, the production of NO and ROS, and the proliferation of hFLS in proportion to the concentration of GJB-5. In conclusion, these results shows that GJB-5 had immunomodulatory effects in treating rheumatoid arthritis.
Keywords
Gwanjulbang-5; Rheumatoid Arthritis; immunomodulatory; Pro-inflammatory cytokines; Human fibroblast-like synoviocytes(hFLS);
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