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Effect of Chrysanthemum Morifolium Extracts on the Synthesis of Laminin of Madin-Darby Canine Kidney Cells  

Na, Ho-Jeong (College of Pharmacy, Woosuk University)
Jeon, So-Ra (College of Pharmacy, Woosuk University)
Cha, Dong-Seok (College of Pharmacy, Woosuk University)
Eun, Jae-Soon (College of Pharmacy, Woosuk University)
Lim, Jong-Pil (College of Pharmacy, Woosuk University)
Shin, Tae-Yong (College of Pharmacy, Woosuk University)
Oh, Chan-Ho (Department of Biotechnology Woosuk University)
Yang, Jae-Heon (College of Pharmacy, Woosuk University)
Kim, Dae-Keun (College of Pharmacy, Woosuk University)
Leem, Jae-Yoon (College of Pharmacy, Woosuk University)
Chae, Byeong-Suk (College of Pharmacy, Woosuk University)
Kim, Sung-Zoo (Department of Physiology, Chonbuk National University)
Jung, Yen-Ok (Department of Oriental Herb Science, Masan College)
Jeong, Won-Hwan (Gochang GukHwa Festival Committee)
Jeon, Hoon (College of Pharmacy, Woosuk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.3, 2007 , pp. 709-713 More about this Journal
Abstract
Basement membranes (BMs) are extracellular matrices associated with epithelia, endothelia, muscle, fat and peripheral nerve. They are involved in cell survival, migration, differentiation. BMs functions also include tissue formation and provide mechanical stability as a selective barriers. Laminins are heterotrimeric glycoproteins found in BMs and have a crucial role in cell adhesion and signalling. Madin-Darby canine kidney (MDCK) cells are the best established mammalian model for studying epithelial cell biology The cells form an epithelial monolayer, with tight junctions separating an apical surface from a basolateral membrane facing the filter support and neighboring cells. In this study, using MDCK cells, the synthesis of the BM protein such as laminin with or without methanol extract of Chrysanthemum morifolium (CM) stimulation was analyzed by immunoblotting and CM showed significant increased cell density and enhanced synthesis of laminin.
Keywords
Basement membranes (BMs); laminin; Chrysanthemum morifolium (CM); Madin-Darby canine kidney (MDCK) cells;
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