Browse > Article

Effect of Samul-Tang on the Allergic Inflammatory Response  

Kim, Eun-Kyoung (Department of Anatomy, College of Oriental Medicine, Kyung Hee University)
Kim, Eun-Young (Department of Anatomy, College of Oriental Medicine, Kyung Hee University)
Lee, Hyun-Sam (Department of Anatomy, College of Oriental Medicine, Kyung Hee University)
Jung, Hyuk-Sang (Department of Anatomy, College of Oriental Medicine, Kyung Hee University)
Park, Seong-Kyu (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Sohn, Young-Joo (Department of Gynecology, College of Oriental Medicine, Sangji University)
Sohn, Nak-Won (Department of Anatomy, College of Oriental Medicine, Kyung Hee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.3, 2007 , pp. 617-625 More about this Journal
Abstract
Samul-Tang (SMT) has been used for nourishing of the blood, hematopoiesis as a herbal medicine history. The purpose of this study is to find out anti-allergic inflammatory reaction of SMT. To clarify the mechanism, the effect of SMT on vascular permeability of rat cutaneous tissue and histamine and cytokines (IL-6, IL-8, TNF-${\alpha}$) release from mast cells were observed. The results are the pretreatment with SMT significantly decreased the compound 48/80-induced degranulation and histamine release from RPMC, SMT also inhibited the anti-DNP lgE-induced increment of vascular permeability of rat cutaneous tissue. SMT significantly reduced the PMA plus A23187-induced increment of expression of IL-6, IL-8, and TNF-${\alpha}$ in HMC-1 Cell. The Present study provide evidence that SMT inhibits mast cell-derived inflammatory allergic reactions by blocking histamine release and pro-inflammatory cytokine expression, and suggest the mechanisms of action. Furthermore, in vivo and in vitro anti-allergic effect of SMT suggests a possible therapeutic application of this agent in inflammatory allergic diseases.
Keywords
Samul-Tang; mast cell; histamine; passive cutaneous anaphylaxis (PCA); cytokine;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Moon, P.D., Na, J.J., Jeong, H.J., Hong, S.H., Kim, S.J., Chae, H.J., Kim, H.R., Choi, J.O., Lee, S.H., Shin, J.Y., Kim, H.M. Inhibitory effect of Gamibojungikaitang extract on mast cell-mediated allergicreaction in murine Model. J Pharm Pharm Sci 8(1):94-101, 2005
2 姜昌洙. 四物湯 煎湯液이 家兎의 血壓降下에 미치는 影響. 圓光大學校 韓醫科大學 學位論文集 1: 381-398, 1981
3 Sullivan, T.J., Parker, K.L., Stenson, W., Parker, C.W. Modulation of cyclic AMP in purified rat mast cells. II. Studies on the relationship between intracellular cyclic AMP concentrations and histamine release. J. Immunol 114: 1480-1485, 1975
4 김형민. 면역과 알레르기. 서울, 신일상사, pp 159-173, 1998
5 Salamon, P., Shoham, N.G., Gavrieli, R., Wolach, B., Mekori, Y.A. Human mast cells release Interleukin-8 and induce neutrophil chemotaxis on contact with activated T cells.Allergy 60(10):1316-1319, 2005   DOI   ScienceOn
6 Stankiewicz, W., Dabrowski, M.P., Chcialowski, A., Plusa, T. Cellular and cytokine immunoregulation in patients with chronic obstructive pulmonary disease and bronchial asthma. Mediators Inflamm 11(5):307-312, 2002   DOI   ScienceOn
7 李相弦. 四物湯 構成藥物의 配合이 白鼠의 溶血性 貧血에 미치는 影響. 圓光大學校 大學院 1993
8 金世吉. 四物湯이 貧血家兎의 造血效果에 미치는 影響. 圓光大學校 韓醫科大學 學位論文集 pp 143-152, 1982
9 Ennis, M., Pearce, F.L., Weston, P.M. Some studies on the release of histamine from mast cells stimulated with polylysine. Br. J. Pharmacol 70: 329-334, 1980   DOI   ScienceOn
10 김완수. rHRF로 유발로 활성화된 생쥐의 B 임파구와 비만세포에서 辛夷 추출물의 항알러지 작용에 관한 연구. 동의생리병리학회지 15(6):917-926, 2001
11 Roitt, I., Brostoff, J., Male, D. Immunology, 6th ed. U.S.A., Mosby. pp 323-383. 2001
12 Artuc M, Hermes B, Steckelings UM, Grutzkau A, Henz BM. Mast cells and their mediators in cutaneous wound healing-active participants or innocent by standers. Experimental Dermatology 8: 1-16, 1998
13 이영훈, 한의혁, 송창호. 비만세포의 두얼굴. 천식 및 알레르기 20: 684-690, 2000
14 Zhang, Y.H., Lin, J.X., Vilcek, J. Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence. Mol Cell Biol 10(7):3818-3823, 1990   DOI
15 Kawabe, H., Hayashi, H., Hayaishi, O. Differential calcium effects on prostaglandin D2 generation and histamine release from isolated rat peritoneal mast cells. Biochem. Biophys Res Commun 143(2):467-474, 1987   DOI   ScienceOn
16 강경진, 전병득, 채옥희, 이무삼. 상백피가 흰쥐 복강 비만세포의 히스타민 유리와 Calcium uptake에 미치는 영향. 대한면역학회지 15: 91-99, 1993
17 Dainaka, J., Ichikawa, A., Koibuchi, Y., Nakagawa, M., Tomita, K. Effect of the tridecamer of compound 48/80, a Ca2+-dependent histamine releaser, on phospholipid metabolism during the early stage of histamine release from rat mast cells. Biochem Pharmacol 35(21):3739-3744, 1986   DOI   ScienceOn
18 Kim, S.J., Lee, E.J., Song, Y.S., Jeong, H.J., Lee, K.M., Kim, H.R., Chae, H.J., Shin, T.Y., Kim, Y.K., Hong, S.H., Kim, H.M. Cheongyeolsaseuptang inhibits production of TNF-$\alpha$, IL-6 and IL-8 as well as NF-kB activation in human mast cells. J Ethnopharmacol 97(1):83-88, 2005   DOI   ScienceOn
19 Choi, I.Y., Koo, H.N., Lee, S.H., Shin, J.Y., Chae, H.J., Kim, H.R., Kim, C.H., Hong, S.H., Kim, H.M. Anti-inflmmatory activity of Korean folk medicine 'Sabeksan'. Exp Mol Pathol 78(3):257-262, 2005   DOI   ScienceOn
20 Na, H.J., Moon, P.D., Ko, S.G., Lee, H.J., Jung, H.A., Hong, S.H., Seo, Y., Oh, J.M., Lee, B.H., Choi, B.W., Kim, H.M. Sargassum hemiphyllum Inhibits Atopic Allergic Reaction via the Regulation of Inflammatory Mediators. J Pharmacol Sci 97(2):219-226, 2005   DOI   ScienceOn
21 김은경, 이광소, 채옥희, 송창호. 우방자 추출물의 compound 48/80 유도 비만세포 활성화와 혈관 투과성 억제효과. 대한체질인류학회지 17(1):55-65, 2004
22 Ershler, W.B., Keller, E.T. Age-associated increased interleukin-6 gene expression, late-life deseses, and frailty. Annu Rev Med 51: 245-270, 2000   DOI   ScienceOn
23 李尙仁. 天眞處方解說. 서울, 成輔社, pp 53-57, 1987
24 채옥희, 이종인, 이무삼. 상백피의 colchicine 유도 비만세포 활성화 억제효과. 대한해부학회지 32: 735-747, 1999
25 Kim, H.M., Park, Y.A., Lee, E.J., Shin, T.Y. Inhibition of immediate-type allergic reaction by Rosa davurica Pall. in a murine model. J Ethnnopharmacology 67: 53-60, 1999   DOI   ScienceOn
26 김대식, 김소연, 김춘추, 민창기, 박수정, 서영훈, 엄현석, 정낙균, 정대철, 정태준, 진종률, 한치화. 면역생물학. 서울, 라이프사이언스 pp 461-488, 2001
27 이중달. 그림으로 설명한 병리학. 서울, 고려의학, P 29, 1991
28 Sieghart, W., Theoharides, T.C., Douglas, W.W., Greengard, P. Phosphorylation of a single mast cell protein in response to drugs that inhibit secretion. Biochem Pharmacol 30(19):2737-2738, 1981   DOI   ScienceOn
29 Sullivan, T.J., Parker, C.W. Possible role of arachidonic acid and its metabolites in mediator release from rat mast cells. J Immunol 122(2):431-436, 1979
30 Ehrlich, P. Beitrage zur kenntnis der Anilinfarbunger und ihrer Verwendung in drmikroskopischen Technik. Arch Mikrosk Anast 13: 263-277, 1877   DOI
31 Moller, A., Lippert, U., Lessmann, D., Kolde, G., Hamann, K., Welker, P., Schadendorf, D., Rosenbach, T., Luger, T., Czarnetzki, B.M. Human mast cells produce IL-8. J Immunol 151(6):3261-3266, 1993
32 Na, H.J., Jeong, H.J., Bae, H., Kim, Y.B., Park, S.T., Yun, Y.G., Kim, H.M.. Tongkyutang inhibits mast cell-dependent allergic reactions and inflammatory cytokine secretion. Clinica Chimica Acta 319: 35-41, 2002   DOI   ScienceOn
33 太平惠民和劑局方編. 太平惠民和劑局方. 북경, 인민위생출판사, pp 310-311, 1985
34 Theoharides, T.C., Sieghart, W., Greengard, P., Douglas, W.W. Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein. Science 207(4426):80-82, 1980   DOI