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Effect of Kamicheonmagudeungeum on Hypertension  

Song, Byoung-Yong (Department of Internal medicine, College of Oriental Medicine, Dongshin University)
Hong, Suk (Department of Internal medicine, College of Oriental Medicine, Dongshin University)
Kim, Dong-Hee (Department of Pathology, College of Oriental Medicine, Daejeon University)
Jeon, Sang-Yun (Department of Internal medicine, College of Oriental Medicine, Dongshin University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.2, 2007 , pp. 504-510 More about this Journal
Abstract
Kamicheonmagudeungeum(KCGE), a traditional herbal medicine, has been used as a therapeutic agent for the treatments of acute stage of hypertension. We evaluated the effects of KCGE on hypertension induced by DOCA-salt in rats. The systolic blood pressure and pulse rate significantly lowered by oral administration with KCGE. The levels of plasma hormones including dopamine, epinephrine and norepinephrine, and serum electrolyte were also reduced in KCGE treated rats. In addition, the production of reactive oxigen species (ROS) were greatly decreased by the treatment with KCGE in cultured bovine endothelial cells and angiotensine converting enzyme (ACE) activites were also inhibited by KCGE in a dose dependent manner. This study indicated that KCGE is a safe and effective treatment for hypertension.
Keywords
kamicheonmagudeungeum(KCGE); DOCA-salt; hypertension; free radical;
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Times Cited By KSCI : 3  (Citation Analysis)
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