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Study no the Antidiabetic Effect of Amomum xanthioides Extract  

Lee, Ji-Hyun (Department of Biochemistry, School of Medicine and Institute of Cardiovascular Research)
Zhao, Zheng-Lim (Department of Biochemistry, School of Medicine and Institute of Cardiovascular Research)
Cho, Nam-Pyo (Department of Pathology, School of Dentistry, Chonbuk national University)
Park, Byung-Hyun (Department of Biochemistry, School of Medicine and Institute of Cardiovascular Research)
Kwon, Kang-Beom (Department of Physiology, School of Oriental Medicine, Wonkwang University)
Rho, Hye-Won (Department of Biochemistry, School of Medicine and Institute of Cardiovascular Research)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.2, 2007 , pp. 468-473 More about this Journal
Abstract
The antidiabetic effect of Amomum xanthioides(A. xanthioides) extract was investigated. Alloxan caused the hyperglycemia and hypoinsulinemia by a selective destruction of pancreatic ${\beta}$-cell. Pretreatment of mouse with A. xanthiodies extract for 2 days prior to alloxan administration completely protected hyperglycemia induced by alloxan. In addition, administration of A. xanthioides extract to alloxan-induced diabetic mouse significantly abolished hyperglycemia, hypoinsulinemia, and, the reduction of size and number of insulin-secreting cells induced by alloxan. Administration of A. xanthioides extract to alloxan-induced diabetic mouse rapidly increased pancreatic Reg gene expression to 7 days, and then decreased. In alloxan-diabetic mouse. Reg gene expression was increased at 3 days after alloxan injection, and sustained until 24 days. The present results indicate that A. xanthioides extract contains potentially effective components exhibiting both protection and treatment of alloxan-induced diabetes. These results suggested that the antidiabetic effect of A. xanthoides extract may be mediated through the regeneration of pancreatic ${\beta}$-cells.
Keywords
Amomum xanthioides; alloxan; antidiabetic effect; regeneration;
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