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Effects of Achyranthes Radix and Electroacupuncture on Type II Collagen-Induced Arthritis  

Kim, Gye-Yeop (College of Health & Welfare of Dongshin University)
Seong, Rak-Seon (Team of Herbal Medicine Standardization, Korea Food and Drug Administration)
Kim, Young-Eok (College of Health & Welfare of Dongshin University)
Chang, Mee-Kyung (Department of Diet & Health Management Dongkang College)
Yu, Young-Dae (Department of Rehabilitation Medicine, Wonkwang University Medical Center)
Choi, Ki-Bok (College of Health & Welfare of Dongshin University)
Jeong, Hyun-Woo (Department of Oriental Medicine of Dongshin University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.2, 2007 , pp. 425-431 More about this Journal
Abstract
The purpose of this study was to observe the effects of Achyranthes Radix(AR) and electroacupuncture(EA) in rats with rheumatoid arthritis induced by type II collagen for 28 days. Control group was daily administered 0.9% NaCl 0.5 $m{\ell}$, Group I was daily administered 0.9% NaCl 0.5 $m{\ell}$ to arthritic rats, Group II was orally administered with Achyranthes Radix 500 mg/kg 0.5 $m{\ell}$ to arthritic rats. Group III was given 2 Hz EA of chok samni acupoint(ST36) in the test group for 30 min/days to arthritic rats. Group IV was daily orally administered with Achyranthes Radix 500 mg/kg 0.5 $m{\ell}$ and 2 Hz EA of chok samni acupoint(ST36) in the test group for 30 min/days to arthritic rats. This studies have been designed to evaluate the hind paw edema, assessment of arthritis indices, analgetic effects by analysis of blood chemistry(WBC, CRP, ALP, AST). In each group, histologic observations, Safranin O-fast green stain were observed and analyzed. The following results were obtained. Group II, III, IV were significantly decreased arthritis indices and the rate of paw edema compared with Group I . Especially group IV was the most significantly decreased. The WBC, CRP, AST, ALT was that Group II, III, IV were significantly decreased compared with Group I . In conclusion, Achyranthes Radix and Ea contribute to the improvement of blood chemistry and change in safranin O-fast green by knee joint of arthritic rats.
Keywords
Achyranthes Radix; Electroacupuncture; Rheumatoid arthritis; Safranin O-fast green; blood chemistry;
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