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Effects of 4 Week Exercise on Activation of Extracellular Signal-regulated Kinases and c-Jun N-terminal Kinase Pathways in Rat Tibialis Muscle  

Choi, Suck-Jun (Wonkwang Health Science College)
Shin, Byung-Cheul (College of Oriental Medicine, Wonkwang University)
Park, Han-Su (Graduate School of Physical Education, Kunsan National University)
Kim, Mo-Kyung (Graduate School of Physical Education, Kunsan National University)
Shin, Chul-Ho (Nam Seoul University)
Kim, Min-Sun (Wonkwang University School of Medicine)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.1, 2007 , pp. 76-81 More about this Journal
Abstract
The effect of either low or high intensity four weeks exercise treadmill running on the activation of the extracellular-signal regulated protein kinase (ERK1/2) and the c-Jun N-terminal kinase(JNK) pathways was determined in rat tibialis muscle. Sprague-Dawley rats were assigned to one of three groups: (i) sedentary group(NE; n=10); (ii) low intensity exercise group (8m/min; LIE; n=10); and (iii) high intensity exercise group(28m/min; HIE; n=10). The training regimens were planned so that animals covered the same distance and had similar glycogenutilization for both LIE and HIE exercise sessions. After four weeks exercise, 48 h after the last exercise bout obtained samples. pERK1 increased 1.5 times comparing with the sedentary group in the low intensity group while it increased 11.7 times in high intensity group, in the tibialis of rats. In the low intensity group, pERK2 increased 1.4 times comparing with the sedentary group while it increased 3.3 times in high intensity group. While pJNK1 decreased 0.9 times, comparing with the sedentary group, pJNK2 was increased to 0.5 times in the low intensity group. But in high intensity group, pJNK2 decreased 0.7 times while pJNK1 didn't show any change. In conclusion, Four weeks exercise of different intensities results in tibialis muscle activation of intracellular signal pathways, which may be one mechanism regulating specific adaptations induced by different exercise intensities.
Keywords
Exercise Training; ERK1/2; JNK;
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