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Inhibition of Aqueous Extract from Amomum xanthioides on ${\alpha}$-melnocyte Stimulating Hormone Induced Melanogenesis in B16F10 Cell  

Lee, Soo-Jin (Department of Anatomy, College of Oriental Medicine, Dong -Eui University)
Ye, Jeong-Sook (Department of Anatomy, College of Oriental Medicine, Dong -Eui University)
Choi, Yung-Hyun (Department of Biochemistry, College of Oriental Medicine, Dong -Eui University)
Lee, Yong-Tae (Department of Physiology, College of Oriental Medicine, Dong -Eui University)
Chung, Kyung-Tae (Department of Life Science and Biotechnology, College of Natural Science, Dong-Eui University)
Jeong, Seong-Yun (Korea BIO-IT Foundry center, Pusan National University)
Choi, Byung-Tae (Department of Anatomy, College of Oriental Medicine, Dong -Eui University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.1, 2007 , pp. 50-53 More about this Journal
Abstract
To develope skin-whitening or therapeutic agents against hyperpigmentation, aqueous extract from Amomum xanthioides (AEAX) was evaluated for melanogenesis inhibitory activity in B16F10 melanoma cell. The treatment with AEAX at the 0.5 and 1.0 mg/ml level significantly inhibits the biosynthesis of melanin compared with untreated control. The AEAX-treated cells at the 1.0 mg/ml level were more efficient than commercial arbutin at 0.1 mg/ml. The tyrosinase activity also significantly decreased in AEAX-treated cells at the 0.5 and 1.0 mg/ml level. The Western analyses confirmed the significantly decreased expression of tyrosinase and tyrosinase-related protein-1 by AEAX treatment. These results indicate that AEAX may contribute to the inhibition of melanin biosynthesis through regulating tyrosinase activity and expression and serve as a new candidate in the design of new skin-whitening or therapeutic agents.
Keywords
Amomum xanthioides; melanogenesis; tyrosinase; tyrosinase-related protein;
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1 Kobayashi, T., Imokawa, G., Bennett, D.C., Hearing, V.J. Tyrosinase stabilizaton by Tyrp1 (the brown locus protein). J Biol Chem, 273: 31801-31805, 1998   DOI   ScienceOn
2 Martinez-Esparza, M., Jimenez-Cervantes, C., Solano, F., Lozano, J.A., Garcia-Borron, J.C. Mechanisms of melanogenesis inhibition by tumor necrosis factor-alpha in B16/F10 mouse melanoma cells. Eur J Biochem, 255: 139-146, 1998   DOI   ScienceOn
3 Seiberg, M., Paine, C., Sharlow, E., Andrade-Gordon, P., Costanzo, M., Eisinger, M., Shapiro, S.S. The protease-activated receptor 2 regulates pigmentation via keratinocyte-melanocyte interactions. Exp Cell Res, 254: 25-32, 2000   DOI   ScienceOn
4 Abdel-Malek, Z., Suzuki, I., Tada, A., Im, S., Akcali, C. The melanocortin-1 receptor and human pigmentation. Ann N Y Acad Sci, 885: 117-133, 1999   DOI
5 Prota, G. The chemistry of melanins and melanogenesis. Fortschr Chem Org Naturst, 64: 93-148, 1995
6 Kim, D.S., Park, S.H., Kwon, S.B., Youn, S.W., Park, K.C. Effects of lysophosphatidic acid on melanogenesis. Chem Phy Lipid, 127: 199-206, 2004   DOI   ScienceOn
7 Baurin, N., Arnoult, E., Scior, T., Do, Q.T., Bernard, P. Preliminary screening of some tropical plants for anti-tyrosinase activity. J Ethnopham, 82: 155-158, 2002   DOI   ScienceOn
8 Abdel-Malek, Z., Swope, V.B., Suzuki, I., Akcali, C., Harriger, M.D., Boyce, S.T., Urabe, K., Hearing, V.J. Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. Proc Natl Acad Sci USA, 92: 1789-1793, 1995
9 Ito, S. The IFPCS presidential lecture: a chemist's view of melanogenesis. Pigment Cell Res, 16: 230-236, 2003   DOI   ScienceOn
10 Rescigno, A., Sollai, F., Pisu, B., Rinaldi, A., Sanjust, E. Tyrosinase inhibition: general and applied aspects. J Enzyme Inhib Med Chem, 17: 207-218, 2002   DOI   ScienceOn
11 Sharlow, E.R., Paine, C.S., Babiarz, L., Eisinger, M., Shapiro, S., Seiberg, M. The protease-activated receptor-2 upregulates keratinocyte phagocytosis. J Cell Sci, 113: 3093-3101, 2000
12 Widlund, H.R., Fisher, D.E. Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival. Oncogene, 22: 3035-3041, 2003   DOI   ScienceOn
13 No, J.K., Soung, D.Y., Kim, Y.J., Shim, K.H., Jun, Y.S., Rhee, S.H., Yokozawa, T., Cuhung, H.Y. Inhibition of tyrosinase by green tea components. Life Sci, 65: 241-246, 1999