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Effect of Aralia contientalis water-extracts on the Level of Cholesterol Accumulation in Rat, which were Treated with High-cholesterol Diet  

Shin, Sung-Ahn (Department of Diagnostics and Cardiovascular Medical Research Center, College of Korea Medicne, Dongguk University)
Park, Sun-Dong (Department of Prescription and Cardiovascular Medical Research Center, College of Korea Medicne, Dongguk University)
Choi, Dall-Young (Department of Pathology, College of Korean Medicne, Dongguk University)
Park, Won-Hwan (Department of Diagnostics and Cardiovascular Medical Research Center, College of Korea Medicne, Dongguk University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.1, 2007 , pp. 104-110 More about this Journal
Abstract
Aralia contientalis show several beneficial effects including anti-oxidant effects. Aralia contientalis is used as a therapeutic agent to stop haemorrhages and a tonic to promoted health in Korean and Chinese medicine. The pharmacokinetic profiles of the main Aralia contientalis is still not accurately investigated. In present study, I examined the effects of water extracts of Aralia contientalis on high cholesterol diet atherosclerosis-induced rats in serum and abdominal aorta. A total of 3-week old 9 male rats of Sprague-Dawley were divided into 3 groups and fed with the basal diet (normal group), high cholesterol diet (atherosclerosis induced group) for 8 weeks, high cholesterol diet supplemented with water extracts of Aralia contientalis (Aralia contientalis group) for 2 weeks. And rats were sacrificed, serum lipid level, abodominal aortic anti-oxidant activities and lipid peroxide were measured. These results indicated that serum total cholesterl, LDL-cholesterol, triglycerides concentration significently lowered in Aralia contientalis group than high cholesterol diet group. But HDL-cholesterol concentraion significently higher in Aralia contientalis group than high cholesterol diet group.
Keywords
Aralia contientalis; atherosclerosis; total cholesterl; LDL; triglycerides HDL;
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