Browse > Article

Effects of Nelumbo Folium and Hayopokchun-san on Diabetes Mellitus in Streptozotocin Treated Rats  

Yang, Woong-Mo (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Chang, Mun-Seog (Department of Medicine, Division of Newborn Medicine, Children's Hospital and harvard Medical School)
Park, Wan-Su (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Lee, Byong-Hee (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Kim, Won-Nam (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Kim, San-Woong (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Choi, Dong-Gi (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Lee, Hak-Chul (Department of Oriental Preventive Medicine, College of Oriental Medicine, Dong-Eui University)
Park, Seong-Kyu (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.6, 2006 , pp. 1497-1501 More about this Journal
Abstract
The therapeutic anti-diabetic effect of Nelumbo Folium and a poly herbal formula (NOC) was evaluated in the streptozotocin (STZ 60 mg/kg, I.p.) induced diabetic rats. For this study, test articles were orally administrated once a day from 7 d after STZ-injection for 3 weeks. The fasting blood glucose, body weight, pancreas weight changes, oral glucose tolerance test, hemoglobin Alc (Hb A1c) level changes and the histopathological changes were observed. WNL-treated rat had lower fasting blood glucose levels compared to control group and NOC-treated rat had significantly lower fasting blood glucose levels, compared to control group (p < 0.05). After 21 days of extract treatment, body weight in control was reduced (p < 0.001). WNL and NOC groups were also reduced compared to control group but insignificantly. Pancreas weight of control group was reduced (p < 0.001), but the weight of NOC group were increased (P< 0.05). During the 2 h oral glucose tolerance test (OGTT), WNL group were improved compared to control group (P < 0.05). NOC group were improved compared to control group but insignificantly. WNL and NOC groups had lower Hb Alc level compared to control group. In addition, atrophy of islet and decrease of insulin-producing cells were detected in STZ induced diabetes rats. However, these diabetic changes were decreased in WNL and NOC groups. These results suggest that N. Folium and NOC have favorable effects to inhibit the changes on the fasting blood glucose levels, pancreas weight, glucose tolerance, hemoglobin Alc and the histopathological changes of pancreas in STZ-induced diabetes.
Keywords
Nelumbo Folium; NOC; streptozotocin; diabetes mellitus; OGTT;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 許浚, 東醫寶鑑. 서울, 南山堂. p 98, 140-142, 1990
2 민헌기. 臨床內分泌學. 서울, 고려의학. pp 268-269, 1990
3 이광우, 새로운 당뇨병 치료제, 당뇨병 21(2):39-45, 1997
4 Jung, H.A., Kim, J.E., Chung, H.Y., Choi, J.S. Antioxidant principles of Nelumbo nucifera stamens. Archives of Pharmacal Research 26: 279-285, 2003   DOI
5 Junod, A., Lambert, A.E., Orici, L., Pictet, R., Gonet, A.E., Renol, A. Studies of the Diabetogenic action of streptozotocin. Proc Soc Exp Biol Med. 126, 201-205, 1967
6 Reaven, G.M., The role of insulin resistance and hyper- insulinemia in coronary heart disease, Metabolism 41, 16-19, 1992   DOI   ScienceOn
7 Bensky, D., Clavey, S., Stoger, E. (Eds.). Materia Medica, third ed. USA, Eastland Press Inc. pp. 193-194, 2004
8 Boden, G. Perspectives in diabetes. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 45: 3-10, 1996   DOI
9 杜鎬京. 臨床腎系學硏究. 서울, 成輔社. pp 526-582, 1995
10 DeFronzo, R.A. Pharmacologic therapy for type 2 diabetes mellitus. Ann Intern Med., 131: 281-303, 1999   DOI   ScienceOn
11 Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 329: 977-986, 1993   DOI   ScienceOn
12 Onishi, E., Yamada, K., Yamada, T., Kaji, K., Inoue, H., Seyama, Y., Yamashita, S. Comparative effects of crude drugs on serum lipids. Chemical and Pharmaceutical Bulletin 32: 646-650, 1984   DOI   ScienceOn
13 Junqueira, V.B., Simiz, K., Videla, L.A., Barros, S.B. Dose Dependent Study of the Effects of Acute Lindane Administration on Rat Liver Superoxide Anion Production Antioxidant Enzyme Activities and Lipid Peroxidation. Toxycology. 41(2):193-204, 1986   DOI   ScienceOn
14 고병섭, 박성규, 최수봉, 전동화, 최미경, 박선민. 오미자 추출물의 혈당 강하 효과에 관한 연구, J. Korean Soc. Appl. Biol. Chem. 47(2):258-264, 2004
15 上海中醫學院. 中醫內科學. 上海, 商務印書館. p 503, 1972
16 Korea National Statistical Office. The Cause of Death Statistics, 2003
17 박선민, 최미경, 전동화, 최수봉, 박성규, 이미영, 김호경, 황영희, 고병섭. 消渴 치료 處方 加減이 3T3-L1 Adipocytes에서 인술린 유사성과 인슐린 민감성에 미치는 영향. 동의생리병리학회지 18(2):451-456, 2004
18 고병섭, 박성규, 최수봉, 전동화, 장진선, 박선민. 오매 추출의 혈당 강하 효과. J Korean Soc Food Sci Nutr. 33(6): 951-957, 2004   DOI
19 杜鎬京. 東醫腎系學(下). 서울, 東洋醫學硏究院. pp 1167-1168, 1993
20 고병섭, 박민정, 박소민, 전원경, 천진미, 정필문, 박선민, 최수봉, 오명숙, 장문석, 박성규. 가미옥천산의 ICR 마우스 경구 투여에 의한 급성 독성시험 연구. 동의생리병리학회지. 19(5):1200-1203, 2005
21 ZMoody, C.S., Hassan, H.M. Mutagenicity of Oxygen Free Radicals. Proc. Natl. Acsd. SCI. 79: 2855-2859, 1982
22 Mun Seog Chang, Myung Sook Oh, Do Rim Kim, Kye Jin Jung, Sunmin Park ,Soo Bong Choi, Byoung-Seob Ko, Seong Kyu Park. Effects of Okchun-San, a herbal formulation, on blood glucose levels and body weight in a model of Type 2 diabetes. Journal of Ethnopharmacology 103: 491-495, 2006   DOI   ScienceOn