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In vitro Cytotoxic Activity of Biflavonoid against P388 Murine Lymphocytic Leukemia Cells  

Lee, Jae-Sook (Department of Beauty Coordiation, Cheongyang College)
Baek, Seung-Hwa (Department of Herbal Resources, professional Graduate School of Oriental Medicine and Institute of Basic Natural Sciences ,Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.5, 2006 , pp. 1290-1294 More about this Journal
Abstract
Biflavonoid (1) showed no antimicrobial activity at a concentration of 150 ${\mu}$g/disc. However, the crude extract of Quintinia acutifolia Kirk inhibited the growth of Bacillus subtilis and the dermatophytic fungus Trichophyton mentagrophytes. 2',3'-Dihydroochanaflavone (1) showed some cytotoxicity with IC$_{50}$ value of 3.1 ${\mu}$g/mL against P388 murine lymphocytic leukemia cells (positive control: mitomycin C IC$_{50}$ 0.06 ${\mu}$g/mL). The structure was determined by Spectroscopic methods.
Keywords
Biflavonoid (1); cytotoxic activity; P388 murine lymphocytic leukemia cells; spectroscopic methods;
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