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Hepatoprotective Lignan Compound from Schizandrae Fructus on Tacrine-induced Cytotoxicity in Hep G2 Cells  

Kim, Hyun-Chul (College of Pharmacy, Wonkwang University)
An, Ren-Bo (College of Pharmacy, Wonkwang University)
Jeong, Gil-Saeng (College of Pharmacy, Wonkwang University)
Bum, Jin-Sun (College of Pharmacy, Wonkwang University)
Oh, Seung-Hwan (College of Pharmacy, Wonkwang University)
Lee, Hye-Suk (College of Pharmacy, Wonkwang University)
Kwon, Ji-Wung (College of Life Sciences and Natural Resources, Wonkwang Univesity)
Kwon, Tae-Oh (College of Life Sciences and Natural Resources, Wonkwang Univesity)
Kim, Youn-Chul (College of Pharmacy, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.5, 2006 , pp. 1282-1284 More about this Journal
Abstract
In the course of search for hepatoprotective agents from oriental traditional medicines, one compound was isolated from the MeOH extract of the fruits of Schizandra chinensis, and its structure was determined as gomisin J(1). The evaluation for hepatoprotective activity of isolated compound 1 on drug-induced cytotoxicity was conducted, and compound 1 showed protective effect with an EC$_{50}$value of 86.0 ${\pm}$ 5.3 ${\mu}$M against tacrine-induced cytotoxicity in Hep G2 cells. One of the well-known hepatoprotective agents, silybin, used as a positive control, and the hepatoprotective effect of compound 1 is similar with that of silybin (EC$_{50}$ value = 90.5 ${\pm}$ 9.8 ${\mu}$M).
Keywords
Schizandrae Fructus; Lignan; Gomisin J; Hepatoprotective; Tacrine; Hep G2;
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1 An, R.B., Oh, H., Kim, Y.C. Phenolic constituents of Galla Rhois with hepatoprotective effects on tacrine- and nitrofurantoin-induced cytotoxicity in Hep G2 cells. Biol. Pharm. Bull. 28:2155-2157, 2005   DOI   ScienceOn
2 Song, E.K., Cho, H., Kim, J.S., Kim, N.Y., An, N.H., Kim, J.A., Lee, S.H., Kim, Y.C. Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa. Planta Med. 67:876-877, 2001   DOI   ScienceOn
3 Seo, S.M., Lee, H.J., Park, Y., Lee, M.K., Park, J.I., Paik, K.H. Lignans from the fruits of Schizandra chinensis and their inhibitory effects on dopamine content in PC12 cells. Nat. Prod. Sci. 10:104-108, 2004
4 Ip, S.P., Poon, M.K., Che, C.T., Ng, K.H., Kong, Y.C., Ko, K.M. Schisandrin B protects against carbon tetrachloride toxicity by enhancing the mitochondrial glutathione redox status in mouse liver. Free Radical Bio. Med. 21:709-712, 1996   DOI   ScienceOn
5 Watkins, P.B., Zimmermann, H.J., Knapp, M.J., Gracon, S.I., Lewis, K.W. Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. J. Am. Med. Assoc. 271:992-998, 1994   DOI   ScienceOn
6 Oh, H., Kim, J.S., Song, E.K., Cho, H., Kim, D.H., Park, S.E., Lee, H.S., Kim, Y.C. Sesquiterpenes with hepatoprotective activity from Cnidium monnieri on tacrine-induced cytotoxicity in Hep G2 cells. Planta Med. 68:748-749, 2002   DOI   ScienceOn
7 Lee, I.S., Lee, H.K., Dat, N.T., Lee, M.S., Kim, J.W., Na, D.S., Kim, Y.H. Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis. Planta Med. 69:6364, 2003
8 Halliwell, B. Free radicals, antioxidants and human disease: curiosity, cause or consequence? Lancet, 344:721-724, 1994   DOI   ScienceOn
9 Zhu, Y.P. Chinese Materia Medica. Amsterdam, The Netherlands, Harwood Academic Publishers. p 653, 1998
10 Choi, Y.W., Takamatsu, S., Khan, S.I., Srinivas, P.V., Ferreira, D., Zhao, J., Khan, I.A. Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans. J. Nat. Prod. 69:356-359, 2006   DOI   ScienceOn
11 Kim, S.R., Lee, M.K., Koo, K.A., Kim, S.H., Sung, S.H., Lee, N.G., Markelonis, G.J., Oh, T.H., Yang, J.H., Kim, Y.C. Dibenzocyclooctadiene lignans from Schisandra chinensisprotect primary cultures of rat cortical cells from glutamate-induced toxicity. J. Neurosci. Res. 76:397-405, 2004   DOI   ScienceOn
12 Pan, S.Y., Han, Y.F., Carlier, P.R., Pang, Y.P., Mak, D.H.F., Lam, B.Y.H., Ko, K.M., Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice. Planta Med. 68:217-220, 2002   DOI   ScienceOn
13 An, R.B., Sohn, D.H., Kim, Y.C. Hepatoprotective compounds of the roots of Cudrania tricuspidata on tacrine-induced cytotoxicity in Hep G2 cells. Biol. Pharm. Bull. 29:838-840, 2006   DOI   ScienceOn
14 Hikino, H., Kiso, Y., Taguchi, H., Ikeya, Y. Antihepatotoxic actions of lignoids from Schizandra chinensis fruits. Planta Med. 50:213-218, 1984   DOI   ScienceOn